Identity
HGNC
LOCATION
3p21.2
LOCUSID
ALIAS
BACTS2,CIS,CIS-1,G18,SOCS
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1154
MIM: 602441
HGNC: 1984
Ensembl: ENSG00000114737
Variants:
dbSNP: 1154
ClinVar: 1154
TCGA: ENSG00000114737
COSMIC: CISH
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000114737 | ENST00000348721 | Q9NSE2 |
| ENSG00000114737 | ENST00000443053 | Q9NSE2 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37118554 | 2023 | CISH impairs lysosomal function in activated T cells resulting in mitochondrial DNA release and inflammaging. | 6 |
| 37563692 | 2023 | CIS deletion by CRISPR/Cas9 enhances human primary natural killer cell functions against allogeneic glioblastoma. | 5 |
| 37118554 | 2023 | CISH impairs lysosomal function in activated T cells resulting in mitochondrial DNA release and inflammaging. | 6 |
| 37563692 | 2023 | CIS deletion by CRISPR/Cas9 enhances human primary natural killer cell functions against allogeneic glioblastoma. | 5 |
| 34072601 | 2021 | Genetic Predisposition to the Mortality in Septic Shock Patients: From GWAS to the Identification of a Regulatory Variant Modulating the Activity of a CISH Enhancer. | 10 |
| 34072601 | 2021 | Genetic Predisposition to the Mortality in Septic Shock Patients: From GWAS to the Identification of a Regulatory Variant Modulating the Activity of a CISH Enhancer. | 10 |
| 32097462 | 2020 | NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS. | 45 |
| 32961483 | 2020 | MiR-944/CISH mediated inflammation via STAT3 is involved in oral cancer malignance by cigarette smoking. | 20 |
| 32097462 | 2020 | NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS. | 45 |
| 32961483 | 2020 | MiR-944/CISH mediated inflammation via STAT3 is involved in oral cancer malignance by cigarette smoking. | 20 |
| 30197185 | 2019 | CISH is a negative regulator of IL-13-induced CCL26 production in lung fibroblasts. | 8 |
| 30197185 | 2019 | CISH is a negative regulator of IL-13-induced CCL26 production in lung fibroblasts. | 8 |
| 29325454 | 2018 | Down-expression of P2RX2, KCNQ5, ERBB3 and SOCS3 through DNA hypermethylation in elderly women with presbycusis. | 18 |
| 29593227 | 2018 | The Cish SH2 domain is essential for PLC-γ1 regulation in TCR stimulated CD8(+) T cells. | 14 |
| 29920655 | 2018 | Genetic contribution of suppressor of cytokine signalling polymorphisms to the susceptibility to infection after traumatic injury. | 3 |
Citation
Dessen P
CISH (cytokine inducible SH2 containing protein)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45611/cish
