CKAP2 (cytoskeleton associated protein 2)

2014-05-01  

Identity

HGNC
CKAP2
LOCATION
13q14.3
LOCUSID
26586
ALIAS
LB1,TMAP,se20-10
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 26586
MIM: 611569
HGNC: 1990
Ensembl: ENSG00000136108

Variants:

dbSNP: 26586
ClinVar: 26586
TCGA: ENSG00000136108
COSMIC: CKAP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136108ENST00000258607Q8WWK9
ENSG00000136108ENST00000378034Q8WWK9
ENSG00000136108ENST00000378037Q8WWK9
ENSG00000136108ENST00000468284C9J649
ENSG00000136108ENST00000480747C9J7Y4
ENSG00000136108ENST00000490903Q8WWK9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
173767722007CKAP2 is a spindle-associated protein degraded by APC/C-Cdh1 during mitotic exit.22
173393422007Functional importance of the anaphase-promoting complex-Cdh1-mediated degradation of TMAP/CKAP2 in regulation of spindle function and cytokinesis.12
168761222006A cytoskeleton-associated protein, TMAP/CKAP2, is involved in the proliferation of human foreskin fibroblasts.9
193692492009Cdk1-cyclin B1-mediated phosphorylation of tumor-associated microtubule-associated protein/cytoskeleton-associated protein 2 in mitosis.9
242381252014Cytoskeleton-associated protein 2 is a potential predictive marker for risk of early and extensive recurrence of hepatocellular carcinoma after operative resection.6
248872652014Chromatin CKAP2, a new proliferation marker, as independent prognostic indicator in breast cancer.6
204581742010Specific primary sequence requirements for Aurora B kinase-mediated phosphorylation and subcellular localization of TMAP during mitosis.5
224651202012Cyclin A regulates a cell-cycle-dependent expression of CKAP2 through phosphorylation of Sp1.4
300669462018CKAP2 expression is associated with glioma tumor growth and acts as a prognostic factor in high‑grade glioma.4
237379872013CKAP2 ensures chromosomal stability by maintaining the integrity of microtubule nucleation sites.3

Citation

Dessen P

CKAP2 (cytoskeleton associated protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-05-01

Online version: http://atlasgeneticsoncology.org/gene/53897/ckap2