CLASP1 (cytoplasmic linker associated protein 1)

2016-10-01  

Identity

HGNC
LOCATION
2q14.2
LOCUSID
ALIAS
MAST1
FUSION GENES

Other Information

Locus ID:

NCBI: 23332
MIM: 605852
HGNC: 17088
Ensembl: ENSG00000074054

Variants:

dbSNP: 23332
ClinVar: 23332
TCGA: ENSG00000074054
COSMIC: CLASP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000074054ENST00000263710Q7Z460
ENSG00000074054ENST00000397587Q7Z460
ENSG00000074054ENST00000409078Q7Z460
ENSG00000074054ENST00000418989C9J151
ENSG00000074054ENST00000449975C9JP76
ENSG00000074054ENST00000452274H0Y5T1
ENSG00000074054ENST00000455322F8WA11
ENSG00000074054ENST00000541377Q7Z460
ENSG00000074054ENST00000646274Q7Z460

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Signaling by Robo receptorREACTOMER-HSA-376176
Role of Abl in Robo-Slit signalingREACTOMER-HSA-428890
AURKA Activation by TPX2REACTOMER-HSA-8854518

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
156319942005CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex.179
197011962009Golgi-derived CLASP-dependent microtubules control Golgi organization and polarized trafficking in motile cells.122
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
248590052014CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover.75
218222762011MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis.54
208525892010CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity.51
223073302012CLASPs prevent irreversible multipolarity by ensuring spindle-pole resistance to traction forces during chromosome alignment.35
237272312013A cryptic TOG domain with a distinct architecture underlies CLASP-dependent bipolar spindle formation.25
168668692006Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment.23
195610702009PRC1 cooperates with CLASP1 to organize central spindle plasticity in mitosis.20

Citation

Dessen P

CLASP1 (cytoplasmic linker associated protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/55998/clasp1