CLCA4 (chloride channel accessory 4)

2021-06-01  

Identity

HGNC
LOCATION
1p22.3
LOCUSID
ALIAS
CaCC,CaCC2

Other Information

Locus ID:

NCBI: 22802
MIM: 616857
HGNC: 2018
Ensembl: ENSG00000016602

Variants:

dbSNP: 22802
ClinVar: 22802
TCGA: ENSG00000016602
COSMIC: CLCA4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000016602ENST00000370563Q14CN2

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
Pancreatic secretionKEGGko04972
Pancreatic secretionKEGGhsa04972
Renin secretionKEGGhsa04924
Renin secretionKEGGko04924
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
243863112013Loss of CLCA4 promotes epithelial-to-mesenchymal transition in breast cancer cells.24
154902402004The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis.22
230733142013CLCA4 variants determine the manifestation of the cystic fibrosis basic defect in the intestine.7
303121712018CLCA4 inhibits cell proliferation and invasion of hepatocellular carcinoma by suppressing epithelial-mesenchymal transition via PI3K/AKT signaling.5
308879522019Chloride Channel Accessory 4 (CLCA4) Gene Polymorphisms and Non-Obstructive Azoospermia: A Case-Control Study.2
311646252019Calcium-Activated Chloride Channel A4 (CLCA4) Plays Inhibitory Roles in Invasion and Migration Through Suppressing Epithelial-Mesenchymal Transition via PI3K/AKT Signaling in Colorectal Cancer.2

Citation

Dessen P

CLCA4 (chloride channel accessory 4)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58262/clca4