Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1182
MIM: 600580
HGNC: 2021
Ensembl: ENSG00000109572
Variants:
dbSNP: 1182
ClinVar: 1182
TCGA: ENSG00000109572
COSMIC: CLCN3
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Transmembrane transport of small molecules | REACTOME | R-HSA-382551 |
| Ion channel transport | REACTOME | R-HSA-983712 |
| Stimuli-sensing channels | REACTOME | R-HSA-2672351 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36261097 | 2022 | ClC-3 silencing mediates lysosomal acidification arrest and autophagy inhibition to sensitize chemo-photothermal therapy. | 1 |
| 36261097 | 2022 | ClC-3 silencing mediates lysosomal acidification arrest and autophagy inhibition to sensitize chemo-photothermal therapy. | 1 |
| 33383561 | 2021 | Swelling-activated ClC-3 activity regulates prostaglandin E(2) release in human OUMS-27 chondrocytes. | 4 |
| 34186028 | 2021 | Unique variants in CLCN3, encoding an endosomal anion/proton exchanger, underlie a spectrum of neurodevelopmental disorders. | 13 |
| 33383561 | 2021 | Swelling-activated ClC-3 activity regulates prostaglandin E(2) release in human OUMS-27 chondrocytes. | 4 |
| 34186028 | 2021 | Unique variants in CLCN3, encoding an endosomal anion/proton exchanger, underlie a spectrum of neurodevelopmental disorders. | 13 |
| 32772229 | 2020 | ClC-3 induction protects against cerebral ischemia/reperfusion injury through promoting Beclin1/Vps34-mediated autophagy. | 4 |
| 33069359 | 2020 | Suppression of CLC-3 reduces the proliferation, invasion and migration of colorectal cancer through Wnt/β-catenin signaling pathway. | 11 |
| 33093458 | 2020 | ClC-3/SGK1 regulatory axis enhances the olaparib-induced antitumor effect in human stomach adenocarcinoma. | 9 |
| 32772229 | 2020 | ClC-3 induction protects against cerebral ischemia/reperfusion injury through promoting Beclin1/Vps34-mediated autophagy. | 4 |
| 33069359 | 2020 | Suppression of CLC-3 reduces the proliferation, invasion and migration of colorectal cancer through Wnt/β-catenin signaling pathway. | 11 |
| 33093458 | 2020 | ClC-3/SGK1 regulatory axis enhances the olaparib-induced antitumor effect in human stomach adenocarcinoma. | 9 |
| 30230544 | 2019 | Chloride channel-3 mediates multidrug resistance of cancer by upregulating P-glycoprotein expression. | 15 |
| 30678806 | 2019 | Chloride channel 3 (CIC-3) predicts the tumor size in hepatocarcinoma. | 2 |
| 30905432 | 2019 | Chloride channel-3 is required for efficient tumour cell migration and invasion in human cervical squamous cell carcinoma. | 6 |
Citation
Dessen P
CLCN3 (chloride voltage-gated channel 3)
Atlas Genet Cytogenet Oncol Haematol. 2011-04-01
Online version: http://atlasgeneticsoncology.org/gene/52160/clcn3
