CLDN17 (claudin 17)

2014-07-01  

Identity

HGNC
LOCATION
21q21.3
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 26285
MIM: 617005
HGNC: 2038
Ensembl: ENSG00000156282

Variants:

dbSNP: 26285
ClinVar: 26285
TCGA: ENSG00000156282
COSMIC: CLDN17

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156282ENST00000286808P56750

Expression (GTEx)

0
1
2
3
4

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Tight junctionKEGGko04530
Leukocyte transendothelial migrationKEGGko04670
Cell adhesion molecules (CAMs)KEGGhsa04514
Tight junctionKEGGhsa04530
Leukocyte transendothelial migrationKEGGhsa04670
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Tight junction interactionsREACTOMER-HSA-420029

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
127367072003CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family.23
243257922013The distinct expression patterns of claudin-10, -14, -17 and E-cadherin between adjacent non-neoplastic tissues and gastric cancer tissues.17
261942462016Molecular basis of claudin-17 anion selectivity.5
302190772018Increased expression of claudin-17 promotes a malignant phenotype in hepatocyte via Tyk2/Stat3 signaling and is associated with poor prognosis in patients with hepatocellular carcinoma.3

Citation

Dessen P

CLDN17 (claudin 17)

Atlas Genet Cytogenet Oncol Haematol. 2014-07-01

Online version: http://atlasgeneticsoncology.org/gene/54086/cldn17