CLDN18 (claudin 18)

2007-09-01  

Identity

HGNC
CLDN18
LOCATION
3q22.3
LOCUSID
51208
ALIAS
SFTA5,SFTPJ
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51208
MIM: 609210
HGNC: 2039
Ensembl: ENSG00000066405

Variants:

dbSNP: 51208
ClinVar: 51208
TCGA: ENSG00000066405
COSMIC: CLDN18

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000066405ENST00000183605P56856
ENSG00000066405ENST00000343735P56856
ENSG00000066405ENST00000479660F8WEY4

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Tight junctionKEGGko04530
Leukocyte transendothelial migrationKEGGko04670
Cell adhesion molecules (CAMs)KEGGhsa04514
Tight junctionKEGGhsa04530
Leukocyte transendothelial migrationKEGGhsa04670
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Tight junction interactionsREACTOMER-HSA-420029

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
179322292007Claudin-18: a dominant tight junction protein in Barrett's esophagus and likely contributor to its acid resistance.42
190470872008Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development.40
182233202008New markers of pancreatic cancer identified through differential gene expression analyses: claudin 18 and annexin A8.36
247106532014Aberrantly activated claudin 6 and 18.2 as potential therapy targets in non-small-cell lung cancer.24
247874632014Claudin-18 deficiency results in alveolar barrier dysfunction and impaired alveologenesis in mice.24
272154902017Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma.24
174590572007Gastric and intestinal claudin expression at the invasive front of gastric carcinoma.21
278847002017Claudin-5, -7, and -18 suppress proliferation mediated by inhibition of phosphorylation of Akt in human lung squamous cell carcinoma.17
218321452011Claudin-18 is an early-stage marker of pancreatic carcinogenesis.16
243334682014Expression of claudin-7 and loss of claudin-18 correlate with poor prognosis in gastric cancer.14

Citation

Dessen P

CLDN18 (claudin 18)

Atlas Genet Cytogenet Oncol Haematol. 2007-09-01

Online version: http://atlasgeneticsoncology.org/gene/49740/cldn18