CLDN3 (claudin 3)

2007-02-01  

Identity

HGNC
CLDN3
LOCATION
7q11.23
LOCUSID
1365
ALIAS
C7orf1,CPE-R2,CPETR2,HRVP1,RVP1

Other Information

Locus ID:

NCBI: 1365
MIM: 602910
HGNC: 2045
Ensembl: ENSG00000165215

Variants:

dbSNP: 1365
ClinVar: 1365
TCGA: ENSG00000165215
COSMIC: CLDN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165215ENST00000395145O15551
ENSG00000165215ENST00000395145Q75L79

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Tight junctionKEGGko04530
Leukocyte transendothelial migrationKEGGko04670
Cell adhesion molecules (CAMs)KEGGhsa04514
Tight junctionKEGGhsa04530
Leukocyte transendothelial migrationKEGGhsa04670
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Tight junction interactionsREACTOMER-HSA-420029

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
166276852006The phenotypes of pluripotent human hepatic progenitors.101
129095882003Role of claudin interactions in airway tight junctional permeability.90
159051762005Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells.74
157435082005Claudin-1, -3 and -4 proteins and mRNA expression in benign and malignant breast lesions: a research study.69
152405332004Overexpression of the cell adhesion molecules DDR1, Claudin 3, and Ep-CAM in metaplastic ovarian epithelium and ovarian cancer.63
206552932010Claudin-3 acts as a sealing component of the tight junction for ions of either charge and uncharged solutes.56
284932892017Intestinal epithelial claudins: expression and regulation in homeostasis and inflammation.43
192088072009Claudin-3 gene silencing with siRNA suppresses ovarian tumor growth and metastasis.41
230976312012Tight junction proteins claudin-3 and claudin-4 control tumor growth and metastases.37
194296812009Molecular determinants of the interaction between Clostridium perfringens enterotoxin fragments and claudin-3.36

Citation

Dessen P

CLDN3 (claudin 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46346/cldn3