CLDN5 (claudin 5)

2007-11-01  

Identity

HGNC
LOCATION
22q11.21
LOCUSID
ALIAS
AWAL,BEC1,CPETRL1,TMDVCF,TMVCF
FUSION GENES

Other Information

Locus ID:

NCBI: 7122
MIM: 602101
HGNC: 2047
Ensembl: ENSG00000184113

Variants:

dbSNP: 7122
ClinVar: 7122
TCGA: ENSG00000184113
COSMIC: CLDN5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184113ENST00000403084D3DX19
ENSG00000184113ENST00000406028D3DX19
ENSG00000184113ENST00000413119D3DX19
ENSG00000184113ENST00000618236O00501

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Tight junctionKEGGko04530
Leukocyte transendothelial migrationKEGGko04670
Cell adhesion molecules (CAMs)KEGGhsa04514
Tight junctionKEGGhsa04530
Leukocyte transendothelial migrationKEGGhsa04670
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Tight junction interactionsREACTOMER-HSA-420029

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
127431112003Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice.456
186041992008Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5.199
177615222008Formation of tight junction: determinants of homophilic interaction between classic claudins.136
129095882003Role of claudin interactions in airway tight junctional permeability.90
227008612012Altered DNA methylation profile in idiopathic pulmonary fibrosis.79
218578982011Matrix metalloproteinase-2 and -9 secreted by leukemic cells increase the permeability of blood-brain barrier by disrupting tight junction proteins.63
217723122011Interendothelial claudin-5 expression depends on cerebral endothelial cell-matrix adhesion by β(1)-integrins.47
161584922005Contribution of claudin-5 to barrier properties in tight junctions of epithelial cells.41
231156432012Influenza infects lung microvascular endothelium leading to microvascular leak: role of apoptosis and claudin-5.39
211689352011Tyrosine phosphorylation of VE-cadherin and claudin-5 is associated with TGF-β1-induced permeability of centrally derived vascular endothelium.34

Citation

Dessen P

CLDN5 (claudin 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-11-01

Online version: http://atlasgeneticsoncology.org/gene/49802/cldn5