CLEC12A (C-type lectin domain family 12 member A)

2007-12-01  

Identity

HGNC
CLEC12A
LOCATION
12p13.31
LOCUSID
160364
ALIAS
CD371,CLL-1,CLL1,DCAL-2,MICL

Other Information

Locus ID:

NCBI: 160364
MIM: 612088
HGNC: 31713
Ensembl: ENSG00000172322

Variants:

dbSNP: 160364
ClinVar: 160364
TCGA: ENSG00000172322
COSMIC: CLEC12A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172322ENST00000304361Q5QGZ9
ENSG00000172322ENST00000350667Q5QGZ9
ENSG00000172322ENST00000355690Q5QGZ9
ENSG00000172322ENST00000396507A8MVL9
ENSG00000172322ENST00000434319Q5QGZ9

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
176094282007The novel AML stem cell associated antigen CLL-1 aids in discrimination between normal and leukemic stem cells.103
216771412011Targeting antigen to mouse dendritic cells via Clec9A induces potent CD4 T cell responses biased toward a follicular helper phenotype.66
155487162004C-type lectin-like molecule-1: a novel myeloid cell surface marker associated with acute myeloid leukemia.56
147392802004Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes.47
194942822009The C-type lectin Clec12A present on mouse and human dendritic cells can serve as a target for antigen delivery and enhancement of antibody responses.40
162394262006Dendritic-cell-associated C-type lectin 2 (DCAL-2) alters dendritic-cell maturation and cytokine production.38
168382772006Human MICL (CLEC12A) is differentially glycosylated and is down-regulated following cellular activation.28
183505512008Characterisation of murine MICL (CLEC12A) and evidence for an endogenous ligand.26
293169442018CAR-T cells targeting CLL-1 as an approach to treat acute myeloid leukemia.24
152384212004KLRL1, a novel killer cell lectinlike receptor, inhibits natural killer cell cytotoxicity.13

Citation

Dessen P

CLEC12A (C-type lectin domain family 12 member A)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49855/clec12a