CLEC4G (C-type lectin domain family 4 member G)

2013-11-01  

Identity

HGNC
CLEC4G
LOCATION
19p13.2
LOCUSID
339390
ALIAS
DTTR431,LP2698,LSECtin,UNQ431

Other Information

Locus ID:

NCBI: 339390
MIM: 616256
HGNC: 24591
Ensembl: ENSG00000182566

Variants:

dbSNP: 339390
ClinVar: 339390
TCGA: ENSG00000182566
COSMIC: CLEC4G

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182566ENST00000328853Q6UXB4
ENSG00000182566ENST00000328853Q08G24
ENSG00000182566ENST00000599020M0R277

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
221565242012Identification of cell surface molecules involved in dystroglycan-independent Lassa virus cell entry.67
180832062008Interactions of LSECtin and DC-SIGN/DC-SIGNR with viral ligands: Differential pH dependence, internalization and virion binding.35
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
246230902014Distinct usage of three C-type lectins by Japanese encephalitis virus: DC-SIGN, DC-SIGNR, and LSECtin.16
186978252008Polymorphisms in the C-type lectin genes cluster in chromosome 19 and predisposition to severe acute respiratory syndrome coronavirus (SARS-CoV) infection.11
191110202009The pathogen receptor liver and lymph node sinusoidal endotelial cell C-type lectin is expressed in human Kupffer cells and regulated by PU.1.10
201276792010The DC-SIGN family member LSECtin is a novel ligand of CD44 on activated T cells.10
147118362004Characterization of a novel C-type lectin-like gene, LSECtin: demonstration of carbohydrate binding and expression in sinusoidal endothelial cells of liver and lymph node.0
173394242007The DC-SIGN-related lectin LSECtin mediates antigen capture and pathogen binding by human myeloid cells.0
196322272009Liver sinusoidal endothelial cell lectin, LSECtin, negatively regulates hepatic T-cell immune response.0

Citation

Dessen P

CLEC4G (C-type lectin domain family 4 member G)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53604/clec4g