CLK2 (CDC like kinase 2)

2003-11-01  

Identity

HGNC
LOCATION
1q22
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 1196
MIM: 602989
HGNC: 2069
Ensembl: ENSG00000176444

Variants:

dbSNP: 1196
ClinVar: 1196
TCGA: ENSG00000176444
COSMIC: CLK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000176444ENST00000355560B1AVT0
ENSG00000176444ENST00000361168P49760
ENSG00000176444ENST00000368361P49760
ENSG00000176444ENST00000368361A8K7I0

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
191684422009Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells.21
216828872011Differential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapy.21
256701692015CLK2 Is an Oncogenic Kinase and Splicing Regulator in Breast Cancer.17
206827682010Phosphorylation of CLK2 at serine 34 and threonine 127 by AKT controls cell survival after ionizing radiation.10
270503662016Cdc2-like kinase 2 is a key regulator of the cell cycle via FOXO3a/p27 in glioblastoma.9
271265872016Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint.9
233765372013The highly conserved LAMMER/CLK2 protein kinases prevent germ cell overproliferation in Drosophila.0

Citation

Dessen P

CLK2 (CDC like kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40103/clk2