CLPX (caseinolytic mitochondrial matrix peptidase chaperone subunit X)

2015-02-01  

Identity

HGNC
LOCATION
15q22.31
LOCUSID
ALIAS
EPP2
FUSION GENES

Other Information

Locus ID:

NCBI: 10845
MIM: 615611
HGNC: 2088
Ensembl: ENSG00000166855

Variants:

dbSNP: 10845
ClinVar: 10845
TCGA: ENSG00000166855
COSMIC: CLPX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166855ENST00000300107O76031
ENSG00000166855ENST00000300107A0A024R5X7
ENSG00000166855ENST00000559152H0YM48
ENSG00000166855ENST00000559218H0YK07

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
183133822008Diverse pore loops of the AAA+ ClpX machine mediate unassisted and adaptor-dependent recognition of ssrA-tagged substrates.67
250838742014Stochastic but highly coordinated protein unfolding and translocation by the ClpXP proteolytic machine.48
161158762005Human mitochondrial ClpP is a stable heptamer that assembles into a tetradecamer in the presence of ClpX.25
273895352016The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis.24
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
261429272015ClpX stimulates the mitochondrial unfolded protein response (UPRmt) in mammalian cells.16
228414772012Maintenance of mitochondrial genome distribution by mitochondrial AAA+ protein ClpX.12
288745912017Mutation in human CLPX elevates levels of δ-aminolevulinate synthase and protoporphyrin IX to promote erythropoietic protoporphyria.11
227100822012Substrate recognition and processing by a Walker B mutant of the human mitochondrial AAA+ protein CLPX.8

Citation

Dessen P

CLPX (caseinolytic mitochondrial matrix peptidase chaperone subunit X)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/55068/clpx