Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CMKLR1 (chemerin chemokine-like receptor 1)

Identity

Alias_nameschemokine-like receptor 1
Alias_symbol (synonym)RVER1
Other aliasCHEMERINR
ChemR23
DEZ
HGNC (Hugo) CMKLR1
LocusID (NCBI) 1240
Atlas_Id 54222
Location 12q23.3  [Link to chromosome band 12q23]
Location_base_pair Starts at 108288046 and ends at 108339311 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CMKLR1 (12q23.3) / HNF1A (12q24.31)ROCK1 (18q11.1) / CMKLR1 (12q23.3)ROCK2 (2p25.1) / CMKLR1 (12q23.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(12;12)(q23;q24) CMKLR1/HNF1A
t(12;18)(q23;q11) ROCK1/CMKLR1

External links

Nomenclature
HGNC (Hugo)CMKLR1   2121
Cards
Entrez_Gene (NCBI)CMKLR1  1240  chemerin chemokine-like receptor 1
AliasesCHEMERINR; ChemR23; DEZ; RVER1
GeneCards (Weizmann)CMKLR1
Ensembl hg19 (Hinxton)ENSG00000174600 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000174600 [Gene_View]  ENSG00000174600 [Sequence]  chr12:108288046-108339311 [Contig_View]  CMKLR1 [Vega]
ICGC DataPortalENSG00000174600
TCGA cBioPortalCMKLR1
AceView (NCBI)CMKLR1
Genatlas (Paris)CMKLR1
WikiGenes1240
SOURCE (Princeton)CMKLR1
Genetics Home Reference (NIH)CMKLR1
Genomic and cartography
GoldenPath hg38 (UCSC)CMKLR1  -     chr12:108288046-108339311 -  12q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CMKLR1  -     12q23.3   [Description]    (hg19-Feb_2009)
GoldenPathCMKLR1 - 12q23.3 [CytoView hg19]  CMKLR1 - 12q23.3 [CytoView hg38]
Genome Data Viewer NCBICMKLR1 [Mapview hg19]  
OMIM602351   
Gene and transcription
Genbank (Entrez)AB112777 AK126405 AK291800 AY497547 BC106927
RefSeq transcript (Entrez)NM_001142343 NM_001142344 NM_001142345 NM_004072
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CMKLR1
Alternative Splicing GalleryENSG00000174600
Gene ExpressionCMKLR1 [ NCBI-GEO ]   CMKLR1 [ EBI - ARRAY_EXPRESS ]   CMKLR1 [ SEEK ]   CMKLR1 [ MEM ]
Gene Expression Viewer (FireBrowse)CMKLR1 [ Firebrowse - Broad ]
GenevisibleExpression of CMKLR1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1240
GTEX Portal (Tissue expression)CMKLR1
Human Protein AtlasENSG00000174600-CMKLR1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99788   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99788  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99788
Splice isoforms : SwissVarQ99788
PhosPhoSitePlusQ99788
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)Chemokine-like_recpt_1    Formyl_rcpt-rel    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)CMKLR1
DMDM Disease mutations1240
SuperfamilyQ99788
Human Protein Atlas [tissue]ENSG00000174600-CMKLR1 [tissue]
Peptide AtlasQ99788
HPRD03829
IPIIPI00017843   IPI00215678   IPI00441140   IPI01022750   IPI01022938   
Protein Interaction databases
DIP (DOE-UCLA)Q99788
IntAct (EBI)Q99788
FunCoupENSG00000174600
BioGRIDCMKLR1
STRING (EMBL)CMKLR1
ZODIACCMKLR1
Ontologies - Pathways
QuickGOQ99788
Ontology : AmiGOskeletal system development  complement receptor mediated signaling pathway  complement receptor activity  G protein-coupled receptor activity  G protein-coupled receptor activity  chemokine receptor activity  protein binding  plasma membrane  plasma membrane  plasma membrane  integral component of plasma membrane  chemotaxis  chemotaxis  inflammatory response  immune response  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  phospholipase C-activating G protein-coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  positive regulation of macrophage chemotaxis  positive regulation of macrophage chemotaxis  integral component of membrane  negative regulation of NF-kappaB transcription factor activity  negative regulation of interleukin-12 production  signaling receptor activity  positive regulation of fat cell differentiation  regulation of calcium-mediated signaling  regulation of calcium-mediated signaling  chemokine-mediated signaling pathway  positive regulation of cold-induced thermogenesis  
Ontology : EGO-EBIskeletal system development  complement receptor mediated signaling pathway  complement receptor activity  G protein-coupled receptor activity  G protein-coupled receptor activity  chemokine receptor activity  protein binding  plasma membrane  plasma membrane  plasma membrane  integral component of plasma membrane  chemotaxis  chemotaxis  inflammatory response  immune response  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  phospholipase C-activating G protein-coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  positive regulation of macrophage chemotaxis  positive regulation of macrophage chemotaxis  integral component of membrane  negative regulation of NF-kappaB transcription factor activity  negative regulation of interleukin-12 production  signaling receptor activity  positive regulation of fat cell differentiation  regulation of calcium-mediated signaling  regulation of calcium-mediated signaling  chemokine-mediated signaling pathway  positive regulation of cold-induced thermogenesis  
NDEx NetworkCMKLR1
Atlas of Cancer Signalling NetworkCMKLR1
Wikipedia pathwaysCMKLR1
Orthology - Evolution
OrthoDB1240
GeneTree (enSembl)ENSG00000174600
Phylogenetic Trees/Animal Genes : TreeFamCMKLR1
HOGENOMQ99788
Homologs : HomoloGeneCMKLR1
Homology/Alignments : Family Browser (UCSC)CMKLR1
Gene fusions - Rearrangements
Fusion : MitelmanCMKLR1/HNF1A [12q23.3/12q24.31]  
Fusion : MitelmanROCK1/CMKLR1 [18q11.1/12q23.3]  
Fusion : QuiverCMKLR1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCMKLR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CMKLR1
dbVarCMKLR1
ClinVarCMKLR1
1000_GenomesCMKLR1 
Exome Variant ServerCMKLR1
GNOMAD BrowserENSG00000174600
Varsome BrowserCMKLR1
Genetic variants : HAPMAP1240
Genomic Variants (DGV)CMKLR1 [DGVbeta]
DECIPHERCMKLR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCMKLR1 
Mutations
ICGC Data PortalCMKLR1 
TCGA Data PortalCMKLR1 
Broad Tumor PortalCMKLR1
OASIS PortalCMKLR1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCMKLR1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCMKLR1
Mutations and Diseases : HGMDCMKLR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutaselect CMKLR1
DgiDB (Drug Gene Interaction Database)CMKLR1
DoCM (Curated mutations)CMKLR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CMKLR1 (select a term)
intoGenCMKLR1
Cancer3DCMKLR1 (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602351   
Orphanet
DisGeNETCMKLR1
MedgenCMKLR1
Genetic Testing Registry CMKLR1
NextProtQ99788 [Medical]
TSGene1240
GENETestsCMKLR1
Open Targets GeneticsENSG00000174600  [validation]
snp3D : Map Gene to Disease1240
BioCentury BCIQCMKLR1
ClinGenCMKLR1
Clinical trials, drugs, therapy
Protein Interactions : CTD1240
Pharm GKB GenePA26640
Clinical trialCMKLR1
Miscellaneous
canSAR (ICR)CMKLR1 (select the gene name)
HarmonizomeCMKLR1
DataMed IndexCMKLR1
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCMKLR1
EVEXCMKLR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jul 11 19:44:00 CEST 2020
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