CMPK1 (cytidine/uridine monophosphate kinase 1)

2012-01-01  

Identity

HGNC
LOCATION
1p33
LOCUSID
ALIAS
CK,CMK,CMPK,UMK,UMP-CMPK,UMPK
FUSION GENES

Other Information

Locus ID:

NCBI: 51727
MIM: 191710
HGNC: 18170
Ensembl: ENSG00000162368

Variants:

dbSNP: 51727
ClinVar: 51727
TCGA: ENSG00000162368
COSMIC: CMPK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162368ENST00000371871Q5T0D2
ENSG00000162368ENST00000371873P30085
ENSG00000162368ENST00000450808A0A494BXC7
ENSG00000162368ENST00000471289E9PJD2

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Pyrimidine metabolismKEGGko00240
Pyrimidine metabolismKEGGhsa00240
Metabolic pathwaysKEGGhsa01100
Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTPKEGGhsa_M00052
Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTPKEGGM00052
MetabolismREACTOMER-HSA-1430728
Metabolism of nucleotidesREACTOMER-HSA-15869
Synthesis and interconversion of nucleotide di- and triphosphatesREACTOMER-HSA-499943

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443622Carcinoma, Non-Small-Cell LungDiseaseClinicalAnnotationassociatedPD21642870
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPKPD21642870, 22838949, 22838950, 24361227
PA445218Pancreatic NeoplasmsDiseaseClinicalAnnotationassociatedPD22838950
PA449014cisplatinChemicalClinicalAnnotationassociatedPD21642870
PA449748gemcitabineChemicalClinicalAnnotationassociatedPKPD21642870, 22838949, 22838950, 24361227
PA450163lamivudineChemicalPathwayassociated

References

Pubmed IDYearTitleCitations
195684092009Gemcitabine-based chemogene therapy for pancreatic cancer using Ad-dCK::UMK GDEPT and TS/RR siRNA strategies.30
119121322002Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates.25
151636602004Substrate-induced conformational changes in human UMP/CMP kinase.20
216428702011Differential effect of polymorphisms of CMPK1 and RRM1 on survival in advanced non-small cell lung cancer patients treated with gemcitabine or taxane/cisplatinum.12
284141002017Cytidine monophosphate kinase is inhibited by the TGF-β signalling pathway through the upregulation of miR-130b-3p in human epithelial ovarian cancer.10
155506762005Phosphorylation of Cytidine, Deoxycytidine, and Their Analog Monophosphates by Human UMP/CMP Kinase Is Differentially Regulated by ATP and Magnesium.9
249631612014CMPK1 and RBP3 are associated with corneal curvature in Asian populations.7
228389502012Effect of genetic polymorphisms on therapeutic response and clinical outcomes in pancreatic cancer patients treated with gemcitabine.5
176087252007Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives -- a screening based on affinity for the UMP-CMP binding site.4
256590342015The contribution of CMP kinase to the efficiency of DNA repair.3

Citation

Dessen P

CMPK1 (cytidine/uridine monophosphate kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-01-01

Online version: http://atlasgeneticsoncology.org/gene/52552/cmpk1