CNMD (chondromodulin)

2016-12-01  

Identity

HGNC
CNMD
LOCATION
13q14.3
LOCUSID
11061
ALIAS
BRICD3,CHM-I,CHM1,LECT1,MYETS1

Other Information

Locus ID:

NCBI: 11061
MIM: 605147
HGNC: 17005
Ensembl: ENSG00000136110

Variants:

dbSNP: 11061
ClinVar: 11061
TCGA: ENSG00000136110
COSMIC: CNMD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136110ENST00000377962O75829
ENSG00000136110ENST00000431550E9PKI9
ENSG00000136110ENST00000448904O75829

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
169809692006Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis.48
180774492008Hypoxia promotes the differentiated human articular chondrocyte phenotype through SOX9-dependent and -independent pathways.40
151074202004Methylation in the core-promoter region of the chondromodulin-I gene determines the cell-specific expression by regulating the binding of transcriptional activator Sp3.18
206638862010Histone modifiers, YY1 and p300, regulate the expression of cartilage-specific gene, chondromodulin-I, in mesenchymal stem cells.15
200261082010Impairment of VEGF-A-stimulated lamellipodial extensions and motility of vascular endothelial cells by chondromodulin-I, a cartilage-derived angiogenesis inhibitor.10
179801512008Cell-specific epigenetic regulation of ChM-I gene expression: crosstalk between DNA methylation and histone acetylation.8
231438792013Chondromodulin-I derived from the inner meniscus prevents endothelial cell proliferation.6
283193202017The endochondral bone protein CHM1 sustains an undifferentiated, invasive phenotype, promoting lung metastasis in Ewing sarcoma.6
161428562005Association of chondromodulin-II Val58Ile polymorphism with radiographic joint destruction in rheumatoid arthritis.5
270352282016Transfection of chondromodulin I into human breast cancer cells and its effect on the inhibition of cancer cell growth.3

Citation

Dessen P

CNMD (chondromodulin)

Atlas Genet Cytogenet Oncol Haematol. 2016-12-01

Online version: http://atlasgeneticsoncology.org/gene/56636/cnmd