CNOT2 (CCR4-NOT transcription complex subunit 2)

2003-12-01  

Identity

HGNC
LOCATION
12q15
LOCUSID
ALIAS
CDC36,HSPC131,IDNADFS,NOT2,NOT2H
FUSION GENES

Other Information

Locus ID:

NCBI: 4848
MIM: 604909
HGNC: 7878
Ensembl: ENSG00000111596

Variants:

dbSNP: 4848
ClinVar: 4848
TCGA: ENSG00000111596
COSMIC: CNOT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111596ENST00000229195Q9NZN8
ENSG00000111596ENST00000229195A0A024RBD8
ENSG00000111596ENST00000418359Q9NZN8
ENSG00000111596ENST00000418359A0A024RBD8
ENSG00000111596ENST00000546673H0YI11
ENSG00000111596ENST00000547780F8VPX5
ENSG00000111596ENST00000547867F8VRJ3
ENSG00000111596ENST00000548159F8VV52
ENSG00000111596ENST00000548338H0YI80
ENSG00000111596ENST00000548599F8VVD4
ENSG00000111596ENST00000548741F8VSK9
ENSG00000111596ENST00000549709H0YHT8
ENSG00000111596ENST00000549750F8VVY1
ENSG00000111596ENST00000550160F8VRS8
ENSG00000111596ENST00000550194F8VX63
ENSG00000111596ENST00000550641F8VUB4
ENSG00000111596ENST00000551043Q9NZN8
ENSG00000111596ENST00000551043A0A024RBD8
ENSG00000111596ENST00000551132F8VWH8
ENSG00000111596ENST00000551661F8VV05
ENSG00000111596ENST00000551710H0YHT6
ENSG00000111596ENST00000551873F8VQD8
ENSG00000111596ENST00000552151A0A087X050
ENSG00000111596ENST00000552231F8VP97
ENSG00000111596ENST00000552319F8VS14
ENSG00000111596ENST00000552483F8VQF4
ENSG00000111596ENST00000552599H0YH84
ENSG00000111596ENST00000552915F8W145
ENSG00000111596ENST00000553020F8VSK9

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
Deadenylation of mRNAREACTOMER-HSA-429947
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainREACTOMER-HSA-6804115

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
241212322013Structure and assembly of the NOT module of the human CCR4-NOT complex.40
212997542011CNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death.26
223677592012Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation.24
147071342004Repression of promoter activity by CNOT2, a subunit of the transcription regulatory Ccr4-not complex.18
167125232006Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex.13
272735142016The transcription factor ERG recruits CCR4-NOT to control mRNA decay and mitotic progression.11
290248112018CNOT2 promotes proliferation and angiogenesis via VEGF signaling in MDA-MB-231 breast cancer cells.11
286156932017The CCR4-NOT complex contributes to repression of Major Histocompatibility Complex class II transcription.5
160396072005The cyclin-dependent kinase 11 interacts with NOT2.4

Citation

Dessen P

CNOT2 (CCR4-NOT transcription complex subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/40114/cnot2