Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CNOT2 (CCR4-NOT transcription complex subunit 2)

Identity

Alias_namesNOT2
CCR4-NOT transcription complex, subunit 2
Alias_symbol (synonym)CDC36
NOT2H
Other aliasHSPC131
HGNC (Hugo) CNOT2
LocusID (NCBI) 4848
Atlas_Id 40114
Location 12q15  [Link to chromosome band 12q15]
Location_base_pair Starts at 70242994 and ends at 70354993 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CNOT2 (12q15) / AHSG (3q27.3)CNOT2 (12q15) / ASTN2 (9q33.1)CNOT2 (12q15) / NUP107 (12q15)
CNOT2 (12q15) / PDE3A (12p12.2)CNOT2 (12q15) / PTMA (2q37.1)CNOT2 (12q15) / PTPRR (12q15)
CNOT2 (12q15) / RAB3IP (12q15)CNOT2 (12q15) / SLC45A4 (8q24.3)FAU (11q13.1) / CNOT2 (12q15)
PCDH9 (13q21.32) / CNOT2 (12q15)CNOT2 12q15 / NUP107 12q15CNOT2 12q15 / PDE3A 12p12.2
CNOT2 12q15 / RAB3IP 12q15CNOT2 12q15 / SLC45A4 8q24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  t(8;12)(q24;q15) CNOT2/SLC45A4
t(9;12)(q33;q15) CNOT2/ASTN2
t(12;12)(p12;q15) CNOT2/PDE3A
t(12;12)(q14;q15) CAND1/CNOT2

External links

Nomenclature
HGNC (Hugo)CNOT2   7878
Cards
Entrez_Gene (NCBI)CNOT2  4848  CCR4-NOT transcription complex subunit 2
AliasesCDC36; HSPC131; NOT2; NOT2H
GeneCards (Weizmann)CNOT2
Ensembl hg19 (Hinxton)ENSG00000111596 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111596 [Gene_View]  ENSG00000111596 [Sequence]  chr12:70242994-70354993 [Contig_View]  CNOT2 [Vega]
ICGC DataPortalENSG00000111596
TCGA cBioPortalCNOT2
AceView (NCBI)CNOT2
Genatlas (Paris)CNOT2
WikiGenes4848
SOURCE (Princeton)CNOT2
Genetics Home Reference (NIH)CNOT2
Genomic and cartography
GoldenPath hg38 (UCSC)CNOT2  -     chr12:70242994-70354993 +  12q15   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CNOT2  -     12q15   [Description]    (hg19-Feb_2009)
GoldenPathCNOT2 - 12q15 [CytoView hg19]  CNOT2 - 12q15 [CytoView hg38]
ImmunoBaseENSG00000111596
Mapping of homologs : NCBICNOT2 [Mapview hg19]  CNOT2 [Mapview hg38]
OMIM604909   
Gene and transcription
Genbank (Entrez)AA234384 AF044215 AF113226 AF161480 AF180473
RefSeq transcript (Entrez)NM_001199302 NM_001199303 NM_014515
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CNOT2
Cluster EST : UnigeneHs.730666 [ NCBI ]
CGAP (NCI)Hs.730666
Alternative Splicing GalleryENSG00000111596
Gene ExpressionCNOT2 [ NCBI-GEO ]   CNOT2 [ EBI - ARRAY_EXPRESS ]   CNOT2 [ SEEK ]   CNOT2 [ MEM ]
Gene Expression Viewer (FireBrowse)CNOT2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4848
GTEX Portal (Tissue expression)CNOT2
Human Protein AtlasENSG00000111596-CNOT2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NZN8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NZN8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NZN8
Splice isoforms : SwissVarQ9NZN8
PhosPhoSitePlusQ9NZN8
Domains : Interpro (EBI)CCR4-NOT_su2/3/5_N_sf    NOT   
Domain families : Pfam (Sanger)NOT2_3_5 (PF04153)   
Domain families : Pfam (NCBI)pfam04153   
Conserved Domain (NCBI)CNOT2
DMDM Disease mutations4848
Blocks (Seattle)CNOT2
PDB (RSDB)4C0D    4C0F    5FU6    5FU7   
PDB Europe4C0D    4C0F    5FU6    5FU7   
PDB (PDBSum)4C0D    4C0F    5FU6    5FU7   
PDB (IMB)4C0D    4C0F    5FU6    5FU7   
Structural Biology KnowledgeBase4C0D    4C0F    5FU6    5FU7   
SCOP (Structural Classification of Proteins)4C0D    4C0F    5FU6    5FU7   
CATH (Classification of proteins structures)4C0D    4C0F    5FU6    5FU7   
SuperfamilyQ9NZN8
Human Protein Atlas [tissue]ENSG00000111596-CNOT2 [tissue]
Peptide AtlasQ9NZN8
HPRD05367
IPIIPI00005011   IPI00410621   IPI00410622   IPI00410623   IPI00017733   IPI00452755   IPI00442877   IPI01022977   IPI01023019   IPI01022858   IPI01022708   IPI01022010   IPI01020897   IPI01022326   IPI01022505   IPI01021364   IPI01025585   IPI01021693   IPI01021854   IPI01021202   IPI01022519   IPI01022686   IPI01023009   IPI01022165   IPI01022323   IPI01022487   IPI01022670   IPI01025434   
Protein Interaction databases
DIP (DOE-UCLA)Q9NZN8
IntAct (EBI)Q9NZN8
FunCoupENSG00000111596
BioGRIDCNOT2
STRING (EMBL)CNOT2
ZODIACCNOT2
Ontologies - Pathways
QuickGOQ9NZN8
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  nuclear-transcribed mRNA poly(A) tail shortening  P-body  RNA polymerase II transcription corepressor binding  trophectodermal cell differentiation  transcription coregulator activity  poly(A)-specific ribonuclease activity  protein binding  nucleus  nucleus  cytoplasm  cytosol  cytosol  plasma membrane  regulation of transcription by RNA polymerase II  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  positive regulation of cytoplasmic mRNA processing body assembly  membrane  negative regulation of translation  CCR4-NOT complex  CCR4-NOT core complex  gene silencing by RNA  negative regulation of intracellular estrogen receptor signaling pathway  RNA phosphodiester bond hydrolysis, exonucleolytic  regulation of stem cell population maintenance  regulation of stem cell population maintenance  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  nuclear-transcribed mRNA poly(A) tail shortening  P-body  RNA polymerase II transcription corepressor binding  trophectodermal cell differentiation  transcription coregulator activity  poly(A)-specific ribonuclease activity  protein binding  nucleus  nucleus  cytoplasm  cytosol  cytosol  plasma membrane  regulation of transcription by RNA polymerase II  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  positive regulation of cytoplasmic mRNA processing body assembly  membrane  negative regulation of translation  CCR4-NOT complex  CCR4-NOT core complex  gene silencing by RNA  negative regulation of intracellular estrogen receptor signaling pathway  RNA phosphodiester bond hydrolysis, exonucleolytic  regulation of stem cell population maintenance  regulation of stem cell population maintenance  
Pathways : KEGGRNA degradation   
NDEx NetworkCNOT2
Atlas of Cancer Signalling NetworkCNOT2
Wikipedia pathwaysCNOT2
Orthology - Evolution
OrthoDB4848
GeneTree (enSembl)ENSG00000111596
Phylogenetic Trees/Animal Genes : TreeFamCNOT2
HOGENOMQ9NZN8
Homologs : HomoloGeneCNOT2
Homology/Alignments : Family Browser (UCSC)CNOT2
Gene fusions - Rearrangements
Fusion : MitelmanCNOT2/ASTN2 [12q15/9q33.1]  
Fusion : MitelmanCNOT2/PDE3A [12q15/12p12.2]  [t(12;12)(p12;q15)]  
Fusion : MitelmanCNOT2/SLC45A4 [12q15/8q24.3]  [t(8;12)(q24;q15)]  
Fusion PortalCNOT2 12q15 NUP107 12q15 BRCA
Fusion PortalCNOT2 12q15 PDE3A 12p12.2 BRCA
Fusion PortalCNOT2 12q15 RAB3IP 12q15 BRCA LUAD
Fusion PortalCNOT2 12q15 SLC45A4 8q24.3 BRCA
Fusion : QuiverCNOT2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCNOT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CNOT2
dbVarCNOT2
ClinVarCNOT2
1000_GenomesCNOT2 
Exome Variant ServerCNOT2
ExAC (Exome Aggregation Consortium)ENSG00000111596
GNOMAD BrowserENSG00000111596
Varsome BrowserCNOT2
Genetic variants : HAPMAP4848
Genomic Variants (DGV)CNOT2 [DGVbeta]
DECIPHERCNOT2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCNOT2 
Mutations
ICGC Data PortalCNOT2 
TCGA Data PortalCNOT2 
Broad Tumor PortalCNOT2
OASIS PortalCNOT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCNOT2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCNOT2
Mutations and Diseases : HGMDCNOT2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CNOT2
DgiDB (Drug Gene Interaction Database)CNOT2
DoCM (Curated mutations)CNOT2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CNOT2 (select a term)
intoGenCNOT2
Cancer3DCNOT2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604909   
Orphanet
DisGeNETCNOT2
MedgenCNOT2
Genetic Testing Registry CNOT2
NextProtQ9NZN8 [Medical]
TSGene4848
GENETestsCNOT2
Target ValidationCNOT2
Huge Navigator CNOT2 [HugePedia]
snp3D : Map Gene to Disease4848
BioCentury BCIQCNOT2
ClinGenCNOT2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4848
Chemical/Pharm GKB GenePA26673
Clinical trialCNOT2
Miscellaneous
canSAR (ICR)CNOT2 (select the gene name)
DataMed IndexCNOT2
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCNOT2
EVEXCNOT2
GoPubMedCNOT2
iHOPCNOT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:38:00 CET 2019
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