Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CNOT4 (CCR4-NOT transcription complex subunit 4)

Identity

Alias_namesNOT4
CCR4-NOT transcription complex, subunit 4
Alias_symbol (synonym)CLONE243
NOT4H
Other alias
HGNC (Hugo) CNOT4
LocusID (NCBI) 4850
Atlas_Id 55380
Location 7q33  [Link to chromosome band 7q33]
Location_base_pair Starts at 135361795 and ends at 135510127 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DTNB (2p23.3) / CNOT4 (7q33)DTNB 2p23.3 / CNOT4 7q33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;7)(p23;q33) DTNB/CNOT4

External links

Nomenclature
HGNC (Hugo)CNOT4   7880
Cards
Entrez_Gene (NCBI)CNOT4  4850  CCR4-NOT transcription complex subunit 4
AliasesCLONE243; NOT4; NOT4H
GeneCards (Weizmann)CNOT4
Ensembl hg19 (Hinxton)ENSG00000080802 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000080802 [Gene_View]  ENSG00000080802 [Sequence]  chr7:135361795-135510127 [Contig_View]  CNOT4 [Vega]
ICGC DataPortalENSG00000080802
TCGA cBioPortalCNOT4
AceView (NCBI)CNOT4
Genatlas (Paris)CNOT4
WikiGenes4850
SOURCE (Princeton)CNOT4
Genetics Home Reference (NIH)CNOT4
Genomic and cartography
GoldenPath hg38 (UCSC)CNOT4  -     chr7:135361795-135510127 -  7q33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CNOT4  -     7q33   [Description]    (hg19-Feb_2009)
GoldenPathCNOT4 - 7q33 [CytoView hg19]  CNOT4 - 7q33 [CytoView hg38]
ImmunoBaseENSG00000080802
Mapping of homologs : NCBICNOT4 [Mapview hg19]  CNOT4 [Mapview hg38]
OMIM604911   
Gene and transcription
Genbank (Entrez)AF091094 AF180475 AK074493 AK074671 AK300365
RefSeq transcript (Entrez)NM_001008225 NM_001190847 NM_001190848 NM_001190849 NM_001190850 NM_013316
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CNOT4
Cluster EST : UnigeneHs.490224 [ NCBI ]
CGAP (NCI)Hs.490224
Alternative Splicing GalleryENSG00000080802
Gene ExpressionCNOT4 [ NCBI-GEO ]   CNOT4 [ EBI - ARRAY_EXPRESS ]   CNOT4 [ SEEK ]   CNOT4 [ MEM ]
Gene Expression Viewer (FireBrowse)CNOT4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4850
GTEX Portal (Tissue expression)CNOT4
Human Protein AtlasENSG00000080802-CNOT4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95628   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95628  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95628
Splice isoforms : SwissVarO95628
PhosPhoSitePlusO95628
Domaine pattern : Prosite (Expaxy)RRM (PS50102)    ZF_C3H1 (PS50103)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)CNOT4_RRM    Nucleotide-bd_a/b_plait_sf    RBD_domain_sf    RRM_dom    RRM_dom_euk    Znf_CCCH    Znf_RING    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00076   
Domain families : Smart (EMBL)RRM_1 (SM00361)  
Conserved Domain (NCBI)CNOT4
DMDM Disease mutations4850
Blocks (Seattle)CNOT4
PDB (RSDB)1E4U    1UR6   
PDB Europe1E4U    1UR6   
PDB (PDBSum)1E4U    1UR6   
PDB (IMB)1E4U    1UR6   
Structural Biology KnowledgeBase1E4U    1UR6   
SCOP (Structural Classification of Proteins)1E4U    1UR6   
CATH (Classification of proteins structures)1E4U    1UR6   
SuperfamilyO95628
Human Protein Atlas [tissue]ENSG00000080802-CNOT4 [tissue]
Peptide AtlasO95628
HPRD05369
IPIIPI00410681   IPI00410682   IPI00410683   IPI00410684   IPI00002436   IPI00410685   IPI00410686   IPI00925697   IPI00902957   IPI01026266   IPI01011519   
Protein Interaction databases
DIP (DOE-UCLA)O95628
IntAct (EBI)O95628
FunCoupENSG00000080802
BioGRIDCNOT4
STRING (EMBL)CNOT4
ZODIACCNOT4
Ontologies - Pathways
QuickGOO95628
Ontology : AmiGOnuclear-transcribed mRNA poly(A) tail shortening  RNA binding  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleus  cytosol  ubiquitin-dependent protein catabolic process  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  protein ubiquitination  CCR4-NOT complex  CCR4-NOT complex  regulation of megakaryocyte differentiation  metal ion binding  protein autoubiquitination  
Ontology : EGO-EBInuclear-transcribed mRNA poly(A) tail shortening  RNA binding  ubiquitin-protein transferase activity  ubiquitin-protein transferase activity  protein binding  nucleus  cytosol  ubiquitin-dependent protein catabolic process  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  protein ubiquitination  CCR4-NOT complex  CCR4-NOT complex  regulation of megakaryocyte differentiation  metal ion binding  protein autoubiquitination  
Pathways : KEGGRNA degradation   
NDEx NetworkCNOT4
Atlas of Cancer Signalling NetworkCNOT4
Wikipedia pathwaysCNOT4
Orthology - Evolution
OrthoDB4850
GeneTree (enSembl)ENSG00000080802
Phylogenetic Trees/Animal Genes : TreeFamCNOT4
HOGENOMO95628
Homologs : HomoloGeneCNOT4
Homology/Alignments : Family Browser (UCSC)CNOT4
Gene fusions - Rearrangements
Fusion : MitelmanDTNB/CNOT4 [2p23.3/7q33]  [t(2;7)(p23;q33)]  
Fusion PortalDTNB 2p23.3 CNOT4 7q33 HNSC
Fusion : QuiverCNOT4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCNOT4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CNOT4
dbVarCNOT4
ClinVarCNOT4
1000_GenomesCNOT4 
Exome Variant ServerCNOT4
ExAC (Exome Aggregation Consortium)ENSG00000080802
GNOMAD BrowserENSG00000080802
Varsome BrowserCNOT4
Genetic variants : HAPMAP4850
Genomic Variants (DGV)CNOT4 [DGVbeta]
DECIPHERCNOT4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCNOT4 
Mutations
ICGC Data PortalCNOT4 
TCGA Data PortalCNOT4 
Broad Tumor PortalCNOT4
OASIS PortalCNOT4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCNOT4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCNOT4
Mutations and Diseases : HGMDCNOT4
intOGen PortalCNOT4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CNOT4
DgiDB (Drug Gene Interaction Database)CNOT4
DoCM (Curated mutations)CNOT4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CNOT4 (select a term)
intoGenCNOT4
Cancer3DCNOT4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604911   
Orphanet
DisGeNETCNOT4
MedgenCNOT4
Genetic Testing Registry CNOT4
NextProtO95628 [Medical]
TSGene4850
GENETestsCNOT4
Target ValidationCNOT4
Huge Navigator CNOT4 [HugePedia]
snp3D : Map Gene to Disease4850
BioCentury BCIQCNOT4
ClinGenCNOT4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4850
Chemical/Pharm GKB GenePA26675
Clinical trialCNOT4
Miscellaneous
canSAR (ICR)CNOT4 (select the gene name)
DataMed IndexCNOT4
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCNOT4
EVEXCNOT4
GoPubMedCNOT4
iHOPCNOT4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 17:38:00 CET 2019
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