CNOT6 (CCR4-NOT transcription complex subunit 6)

2016-10-01  

Identity

HGNC
LOCATION
5q35.3
LOCUSID
ALIAS
CCR4,Ccr4a
FUSION GENES

Other Information

Locus ID:

NCBI: 57472
MIM: 608951
HGNC: 14099
Ensembl: ENSG00000113300

Variants:

dbSNP: 57472
ClinVar: 57472
TCGA: ENSG00000113300
COSMIC: CNOT6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113300ENST00000261951Q9ULM6
ENSG00000113300ENST00000393356Q9ULM6
ENSG00000113300ENST00000504343D6R9H6
ENSG00000113300ENST00000618123Q9ULM6

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
Deadenylation of mRNAREACTOMER-HSA-429947
Developmental BiologyREACTOMER-HSA-1266738
Activation of HOX genes during differentiationREACTOMER-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesisREACTOMER-HSA-5617472
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainREACTOMER-HSA-6804115

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
195583672009Human Ccr4-Not complexes contain variable deadenylase subunits.73
212332832011The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence.39
127711852003BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms.24
181802992008Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1.16
259444462015The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module.11
267924052016miR-29c-3p promotes senescence of human mesenchymal stem cells by targeting CNOT6 through p53-p21 and p16-pRB pathways.8
309266672019Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis.4
188180122009hCCR4/cNOT6 targets DNA-damage response proteins.3
278052842017Susceptibility loci of CNOT6 in the general mRNA degradation pathway and lung cancer risk-A re-analysis of eight GWASs.3

Citation

Dessen P

CNOT6 (CCR4-NOT transcription complex subunit 6)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56453/cnot6