CNOT6L (CCR4-NOT transcription complex subunit 6 like)

2016-10-01  

Identity

HGNC
LOCATION
4q21.1
LOCUSID
ALIAS
CCR4b
FUSION GENES

Other Information

Locus ID:

NCBI: 246175
MIM: 618069
HGNC: 18042
Ensembl: ENSG00000138767

Variants:

dbSNP: 246175
ClinVar: 246175
TCGA: ENSG00000138767
COSMIC: CNOT6L

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138767ENST00000504123Q96LI5
ENSG00000138767ENST00000504804D6RIW9
ENSG00000138767ENST00000512485H0Y9Z5
ENSG00000138767ENST00000515441D6RGK9
ENSG00000138767ENST00000515506H0Y9C1
ENSG00000138767ENST00000649644H0Y9Z5

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
Deadenylation of mRNAREACTOMER-HSA-429947
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainREACTOMER-HSA-6804115

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
206283532010Crystal structure of the human CNOT6L nuclease domain reveals strict poly(A) substrate specificity.43
212332832011The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4-Not complex contribute to the prevention of cell death and senescence.39
174524502007Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth.38
309266672019Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis.4
235918152013Loss of Git2 induces epithelial-mesenchymal transition by miR146a-Cnot6L-controlled expression of Zeb1.3
208187222010A Bayesian approach to genetic association studies with family-based designs.2
270130542016Structural basis for inhibition of the deadenylase activity of human CNOT6L.2
311166652019mRNA levels are buffered upon knockdown of RNA decay and translation factors via adjustment of transcription rates in human HepG2 cells.2
266086072016Post-transcriptional modulation of interleukin 8 by CNOT6L regulates skeletal muscle differentiation.0

Citation

Dessen P

CNOT6L (CCR4-NOT transcription complex subunit 6 like)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56438/cnot6l