CNOT7 (CCR4-NOT transcription complex subunit 7)

2003-06-01  

Identity

HGNC
LOCATION
8p22
LOCUSID
ALIAS
CAF-1,CAF1,Caf1a,hCAF-1
FUSION GENES

Other Information

Locus ID:

NCBI: 29883
MIM: 604913
HGNC: 14101
Ensembl: ENSG00000198791

Variants:

dbSNP: 29883
ClinVar: 29883
TCGA: ENSG00000198791
COSMIC: CNOT7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198791ENST00000361272Q9UIV1
ENSG00000198791ENST00000518021E5RGA8
ENSG00000198791ENST00000518541H0YBT3
ENSG00000198791ENST00000519918H0YAV9
ENSG00000198791ENST00000519954E5RHV9
ENSG00000198791ENST00000520178E5RJE0
ENSG00000198791ENST00000523917Q9UIV1
ENSG00000198791ENST00000524358E5RGH2
ENSG00000198791ENST00000628418E5RHV9

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
Deadenylation of mRNAREACTOMER-HSA-429947
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainREACTOMER-HSA-6804115

References

Pubmed IDYearTitleCitations
195583672009Human Ccr4-Not complexes contain variable deadenylase subunits.73
196055612009The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation.42
232364732012The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex.25
172641522007hCAF1, a new regulator of PRMT1-dependent arginine methylation.23
233860602013hCAF1/CNOT7 regulates interferon signalling by targeting STAT1.12
264711222015A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.11
250384532014CNOT7/hCAF1 is involved in ICAM-1 and IL-8 regulation by tristetraprolin.5
180840942007Crystallization and preliminary crystallographic analysis of the Tob-hCaf1 complex.3
311804912019DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity.3
128456442003Analysis of the transcription regulator, CNOT7, as a candidate chromosome 8 tumor suppressor gene in colorectal cancer.2

Citation

Dessen P

CNOT7 (CCR4-NOT transcription complex subunit 7)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40115/cnot7