Identity
HGNC
LOCATION
5q33.2
LOCUSID
ALIAS
CAF1,CALIF,Caf1b,POP2,hCAF1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9337
MIM: 603731
HGNC: 9207
Ensembl: ENSG00000155508
Variants:
dbSNP: 9337
ClinVar: 9337
TCGA: ENSG00000155508
COSMIC: CNOT8
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33021411 | 2021 | Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4-Not deadenylase in non-Hodgkin lymphoma. | 6 |
| 33021411 | 2021 | Frequent loss of BTG1 activity and impaired interactions with the Caf1 subunit of the Ccr4-Not deadenylase in non-Hodgkin lymphoma. | 6 |
| 31464346 | 2020 | A network-based variable selection approach for identification of modules and biomarker genes associated with end-stage kidney disease. | 4 |
| 31464346 | 2020 | A network-based variable selection approach for identification of modules and biomarker genes associated with end-stage kidney disease. | 4 |
| 25944446 | 2015 | The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module. | 18 |
| 25944446 | 2015 | The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module. | 18 |
| 25038453 | 2014 | CNOT7/hCAF1 is involved in ICAM-1 and IL-8 regulation by tristetraprolin. | 8 |
| 25038453 | 2014 | CNOT7/hCAF1 is involved in ICAM-1 and IL-8 regulation by tristetraprolin. | 8 |
| 24036545 | 2013 | Human CAF-1-dependent nucleosome assembly in a defined system. | 15 |
| 24115769 | 2013 | The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2. | 104 |
| 24036545 | 2013 | Human CAF-1-dependent nucleosome assembly in a defined system. | 15 |
| 24115769 | 2013 | The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2. | 104 |
| 22683897 | 2012 | The N-terminus modulates human Caf1 activity, structural stability and aggregation. | 2 |
| 22977175 | 2012 | The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex. | 62 |
| 23236473 | 2012 | The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex. | 36 |
Citation
Dessen P
CNOT8 (CCR4-NOT transcription complex subunit 8)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/40116/cnot8
