CNOT9 (CCR4-NOT transcription complex subunit 9)

2016-04-01  

Identity

HGNC
CNOT9
LOCATION
2q35
LOCUSID
9125
ALIAS
CAF40,CT129,RCD-1,RCD1,RQCD1

Other Information

Locus ID:

NCBI: 9125
MIM: 612054
HGNC: 10445
Ensembl: ENSG00000144580

Variants:

dbSNP: 9125
ClinVar: 9125
TCGA: ENSG00000144580
COSMIC: CNOT9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144580ENST00000273064Q92600
ENSG00000144580ENST00000273064D5MQE1
ENSG00000144580ENST00000295701Q92600
ENSG00000144580ENST00000418808H7C0W0
ENSG00000144580ENST00000432877F8WBZ6
ENSG00000144580ENST00000433439F8WCV7
ENSG00000144580ENST00000542068Q92600
ENSG00000144580ENST00000542068D5MQE1
ENSG00000144580ENST00000627282Q92600

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
Deadenylation of mRNAREACTOMER-HSA-429947
Developmental BiologyREACTOMER-HSA-1266738
Activation of HOX genes during differentiationREACTOMER-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesisREACTOMER-HSA-5617472
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainREACTOMER-HSA-6804115

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
247685382014Structural and biochemical insights to the role of the CCR4-NOT complex and DDX6 ATPase in microRNA repression.106
247685402014A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing.105
197249022009Involvement of RQCD1 overexpression, a novel cancer-testis antigen, in the Akt pathway in breast cancer cells.18
123567392002Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation.17
181802992008Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1.16
292913912018Tryptophan-Mediated Interactions between Tristetraprolin and the CNOT9 Subunit Are Required for CCR4-NOT Deadenylase Complex Recruitment.10
255447602015Whole exome sequencing identifies a recurrent RQCD1 P131L mutation in cutaneous melanoma.8
208780562010Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis.6
299249582019Overexpression of miR-361-5p in triple-negative breast cancer (TNBC) inhibits migration and invasion by targeting RQCD1 and inhibiting the EGFR/PI3K/Akt pathway.6
303098862018The central region of CNOT1 and CNOT9 stimulates deadenylation by the Ccr4-Not nuclease module.3

Citation

Dessen P

CNOT9 (CCR4-NOT transcription complex subunit 9)

Atlas Genet Cytogenet Oncol Haematol. 2016-04-01

Online version: http://atlasgeneticsoncology.org/gene/55699/cnot9