CNPY2 (canopy FGF signaling regulator 2)

2016-09-01  

Identity

HGNC
CNPY2
LOCATION
12q13.3
LOCUSID
10330
ALIAS
HP10390,MSAP,TMEM4,ZSIG9
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10330
MIM: 605861
HGNC: 13529
Ensembl: ENSG00000257727

Variants:

dbSNP: 10330
ClinVar: 10330
TCGA: ENSG00000257727
COSMIC: CNPY2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000257727ENST00000273308Q9Y2B0
ENSG00000257727ENST00000546466H0YI18
ENSG00000257727ENST00000551286F8W1K5
ENSG00000257727ENST00000551475F8VXJ7
ENSG00000257727ENST00000553191H0YIH9

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
223787872012Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap).25
128266592003MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain.21
255894252015A secreted protein (Canopy 2, CNPY2) enhances angiogenesis and promotes smooth muscle cell migration and proliferation.11
268355372016Decreasing CNPY2 Expression Diminishes Colorectal Tumor Growth and Development through Activation of p53 Pathway.7
282354872017CNPY2 promoted the proliferation of renal cell carcinoma cells and increased the expression of TP53.5
291354542017Expression of a novel CNPY2 isoform in colorectal cancer and its association with oncologic prognosis.4
300709722018Serum CNPY2 isoform 2 represents a novel biomarker for early detection of colorectal cancer.3
295697842018The CNPY2 enhances epithelial-mesenchymal transition via activating the AKT/GSK3β pathway in non-small cell lung cancer.1
304152462018Canopy Homolog 2 Expression Predicts Poor Prognosis in Hepatocellular Carcinoma with Tumor Hemorrhage.1

Citation

Dessen P

CNPY2 (canopy FGF signaling regulator 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-09-01

Online version: http://atlasgeneticsoncology.org/gene/55945/cnpy2