CNR1 (cannabinoid receptor 1)

2007-02-01  

Identity

HGNC
CNR1
LOCATION
6q15
LOCUSID
1268
ALIAS
CANN6,CB-R,CB1,CB1A,CB1K5,CB1R,CNR

Other Information

Locus ID:

NCBI: 1268
MIM: 114610
HGNC: 2159
Ensembl: ENSG00000118432

Variants:

dbSNP: 1268
ClinVar: 1268
TCGA: ENSG00000118432
COSMIC: CNR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118432ENST00000362094F8W908
ENSG00000118432ENST00000369499P21554
ENSG00000118432ENST00000369499S5TLS4
ENSG00000118432ENST00000369501P21554
ENSG00000118432ENST00000369501S5TLS4
ENSG00000118432ENST00000428600P21554
ENSG00000118432ENST00000428600S5TLS4
ENSG00000118432ENST00000468898P21554
ENSG00000118432ENST00000468898V5KA96
ENSG00000118432ENST00000549890P21554
ENSG00000118432ENST00000549890S5TLS4
ENSG00000118432ENST00000551417F8W187

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Retrograde endocannabinoid signalingKEGGhsa04723
Retrograde endocannabinoid signalingKEGGko04723
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
pituitary gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10026aripiprazoleChemicalClinicalAnnotationassociatedPD20107430, 20631561, 23799528
PA128406954Weight gainDiseaseMultilinkAnnotationassociated24279860
PA153906318Autism Spectrum DisorderDiseaseClinicalAnnotationassociatedPD20107430, 20631561, 23799528
PA446878Cocaine-Related DisordersDiseaseClinicalAnnotationassociated
PA447215Psychotic DisordersDiseaseClinicalAnnotationassociatedPD20107430, 20631561, 23799528
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD20107430, 20631561, 23799528
PA449061clozapineChemicalClinicalAnnotationassociatedPD20107430, 20631561, 23799528
PA449072cocaineChemicalClinicalAnnotationassociated
PA449841haloperidolChemicalClinicalAnnotationassociatedPD20107430, 20631561, 23799528
PA450688olanzapineChemicalClinicalAnnotationassociatedPD20107430, 20631561, 23799528
PA451201quetiapineChemicalClinicalAnnotationassociatedPD20107430, 20631561, 23799528
PA451257risperidoneChemicalClinicalAnnotationassociatedPD20107430, 20631561, 23799528

References

Pubmed IDYearTitleCitations
120607832002An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors.222
157288302005Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation.178
167150872006CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis.137
170653422006Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity.129
277688942016Crystal Structure of the Human Cannabinoid Receptor CB<sub>1</sub>.106
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
195982352009Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome.92
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
186069502008Reduced cortical cannabinoid 1 receptor messenger RNA and protein expression in schizophrenia.82
125115872003Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors.80

Citation

Dessen P

CNR1 (cannabinoid receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45964/cnr1