CNR2 (cannabinoid receptor 2)

2007-02-01  

Identity

HGNC
LOCATION
1p36.11
LOCUSID
ALIAS
CB-2,CB2,CX5
FUSION GENES

Other Information

Locus ID:

NCBI: 1269
MIM: 605051
HGNC: 2160
Ensembl: ENSG00000188822

Variants:

dbSNP: 1269
ClinVar: 1269
TCGA: ENSG00000188822
COSMIC: CNR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188822ENST00000374472P34972
ENSG00000188822ENST00000374472A0A024RAH7

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
359933292024Roles of cannabinoid CB1 and CB2 receptors in the modulation of psychostimulant responses.1
380614432024Cannabinoid receptor 2 as a regulator of inflammation induced oleoylethanolamide in eosinophilic asthma.1
383389602024CB2 Cannabinoid Receptor as a Potential Target in Myocardial Infarction: Exploration of Molecular Pathogenesis and Therapeutic Strategies.2
388029792024Single nucleotide polymorphisms in the cannabinoid CB(2) receptor: Molecular pharmacology and disease associations.0
359933292024Roles of cannabinoid CB1 and CB2 receptors in the modulation of psychostimulant responses.1
380614432024Cannabinoid receptor 2 as a regulator of inflammation induced oleoylethanolamide in eosinophilic asthma.1
383389602024CB2 Cannabinoid Receptor as a Potential Target in Myocardial Infarction: Exploration of Molecular Pathogenesis and Therapeutic Strategies.2
388029792024Single nucleotide polymorphisms in the cannabinoid CB(2) receptor: Molecular pharmacology and disease associations.0
341711082023Cannabinoid receptor type 2 gene is associated with comorbidity of schizophrenia and cannabis dependence and fatty acid amide hydrolase gene is associated with cannabis dependence in the Spanish population.6
357174842023Increased expression of CB2 receptor in the intestinal biopsies of children with inflammatory bowel disease.3
368347572023CB2 Receptor as Emerging Anti-Inflammatory Target in Duchenne Muscular Dystrophy.1
368354682023The Anti-Tumorigenic Role of Cannabinoid Receptor 2 in Colon Cancer: A Study in Mice and Humans.2
369778072023Cannabinoid type 2 receptor activation inhibits MPP(+)-induced M1 differentiation of microglia through activating PI3K/Akt/Nrf2 signal pathway.6
371870932023Crosstalk between cannabinoid receptor 2 and lysophosphatidic acid receptor 5.1
372202242023Overexpression of cannabinoid receptor 2 is associated with human breast cancer proliferation, apoptosis, chemosensitivity and prognosis via the PI3K/Akt/mTOR signaling pathway.1

Citation

Dessen P

CNR2 (cannabinoid receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43813/cnr2