CNTN2 (contactin 2)

2003-02-01 Affiliation

Identity

HGNC

CNTN2

LOCATION

1q32.1

LOCUSID

6900

ALIAS

AXT,FAME5,TAG-1,TAX,TAX1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6900
MIM: 190197
HGNC: 2172
Ensembl: ENSG00000184144

Variants:

dbSNP: 6900
ClinVar: 6900
TCGA: ENSG00000184144
COSMIC: CNTN2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000184144	ENST00000331830	Q02246
ENSG00000184144	ENST00000331830	A0A024R9B4
ENSG00000184144	ENST00000532366	A0A1W2PPY1
ENSG00000184144	ENST00000636312	A0A1B0GTL7
ENSG00000184144	ENST00000638378	Q02246
ENSG00000184144	ENST00000638378	A0A024R9B4
ENSG00000184144	ENST00000638577	A0A1W2PR60
ENSG00000184144	ENST00000639122	A0A1W2PQJ4
ENSG00000184144	ENST00000639302	Q02246
ENSG00000184144	ENST00000639302	A0A024R9B4
ENSG00000184144	ENST00000639843	A0A1W2PPQ9
ENSG00000184144	ENST00000639971	A0A1W2PQ86
ENSG00000184144	ENST00000640326	Q02246
ENSG00000184144	ENST00000640326	A0A024R9B4
ENSG00000184144	ENST00000640352	A0A1W2PPY1
ENSG00000184144	ENST00000640428	A0A1W2PQ11

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell adhesion molecules (CAMs)	KEGG	ko04514
Cell adhesion molecules (CAMs)	KEGG	hsa04514
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
NCAM signaling for neurite out-growth	REACTOME	R-HSA-375165
NCAM1 interactions	REACTOME	R-HSA-419037
L1CAM interactions	REACTOME	R-HSA-373760
NrCAM interactions	REACTOME	R-HSA-447038

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19416878	2009	Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals.	58
19086053	2009	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	34
17766378	2007	The crystal structure of the ligand-binding module of human TAG-1 suggests a new mode of homophilic interaction.	22
12139915	2002	Analysis of interactions of the adhesion molecule TAG-1 and its domains with other immunoglobulin superfamily members.	21
24405708	2014	BACE1 activity regulates cell surface contactin-2 levels.	19
27621318	2016	Molecular Architecture of Contactin-associated Protein-like 2 (CNTNAP2) and Its Interaction with Contactin 2 (CNTN2).	17
23518707	2013	Autosomal recessive cortical myoclonic tremor and epilepsy: association with a mutation in the potassium channel associated gene CNTN2.	12
26718491	2016	RACK1 affects glioma cell growth and differentiation through the CNTN2-mediated RTK/Ras/MAPK pathway.	9
19451620	2009	The gray aspects of white matter disease in multiple sclerosis.	8
29684683	2018	Brain-related proteins as potential CSF biomarkers of Alzheimer's disease: A targeted mass spectrometry approach.	8

Citation

Dessen P

CNTN2 (contactin 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40118/cntn2