CNTROB (centrobin, centriole duplication and spindle assembly protein)

2013-06-01  

Identity

HGNC
LOCATION
17p13.1
LOCUSID
ALIAS
LIP8,PP1221
FUSION GENES

Other Information

Locus ID:

NCBI: 116840
MIM: 611425
HGNC: 29616
Ensembl: ENSG00000170037

Variants:

dbSNP: 116840
ClinVar: 116840
TCGA: ENSG00000170037
COSMIC: CNTROB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170037ENST00000380262Q8N137
ENSG00000170037ENST00000563694Q8N137
ENSG00000170037ENST00000565740Q8N137
ENSG00000170037ENST00000570782I3L3N2
ENSG00000170037ENST00000570784I3L465
ENSG00000170037ENST00000571540I3L1A6
ENSG00000170037ENST00000571632I3L1E9
ENSG00000170037ENST00000575408I3L1B0
ENSG00000170037ENST00000576536I3L0P9
ENSG00000170037ENST00000576538I3L1Z8

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
162757502005Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication.55
175358512007Characterization of NIP2/centrobin, a novel substrate of Nek2, and its potential role in microtubule stabilization.28
215763942011Centrobin-tubulin interaction is required for centriole elongation and stability.25
205089832011Centrosome-related genes, genetic variation, and risk of breast cancer.16
201908012010Centrobin regulates the assembly of functional mitotic spindles.15
205116452010Centrobin/NIP2 is a microtubule stabilizer whose activity is enhanced by PLK1 phosphorylation during mitosis.12
256166622015Centrobin-mediated regulation of the centrosomal protein 4.1-associated protein (CPAP) level limits centriole length during elongation stage.10
247004652014Centrobin-centrosomal protein 4.1-associated protein (CPAP) interaction promotes CPAP localization to the centrioles during centriole duplication.9
234428022013Centrobin regulates centrosome function in interphase cells by limiting pericentriolar matrix recruitment.6
232911822013NEK2 phosphorylation antagonizes the microtubule stabilizing activity of centrobin.5

Citation

Dessen P

CNTROB (centrobin, centriole duplication and spindle assembly protein)

Atlas Genet Cytogenet Oncol Haematol. 2013-06-01

Online version: http://atlasgeneticsoncology.org/gene/53355/cntrob