COMT (catechol-O-methyltransferase)

2003-08-01  

Identity

HGNC
COMT
LOCATION
22q11.21
LOCUSID
1312
ALIAS
HEL-S-98n
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1312
MIM: 116790
HGNC: 2228
Ensembl: ENSG00000093010

Variants:

dbSNP: 1312
ClinVar: 1312
TCGA: ENSG00000093010
COSMIC: COMT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000093010ENST00000207636F8WBW9
ENSG00000093010ENST00000361682P21964
ENSG00000093010ENST00000361682A0A140VJG8
ENSG00000093010ENST00000403184E7EUU8
ENSG00000093010ENST00000403710P21964
ENSG00000093010ENST00000403710A0A140VJG8
ENSG00000093010ENST00000406520P21964
ENSG00000093010ENST00000406520A0A140VJG8
ENSG00000093010ENST00000407537P21964
ENSG00000093010ENST00000407537A0A140VJG8
ENSG00000093010ENST00000412786E7EMS6
ENSG00000093010ENST00000428707H7BZ45
ENSG00000093010ENST00000449653P21964

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Steroid hormone biosynthesisKEGGko00140
Tyrosine metabolismKEGGko00350
Steroid hormone biosynthesisKEGGhsa00140
Tyrosine metabolismKEGGhsa00350
Metabolic pathwaysKEGGhsa01100
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Clearance In The Synaptic CleftREACTOMER-HSA-112311
Dopamine clearance from the synaptic cleftREACTOMER-HSA-379401
Enzymatic degradation of dopamine by COMTREACTOMER-HSA-379397
Enzymatic degradation of Dopamine by monoamine oxidaseREACTOMER-HSA-379398
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
MethylationREACTOMER-HSA-156581

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA133822447catecholaminesChemicalVipGeneassociated
PA162263533nephrotoxicityDiseaseClinicalAnnotationassociatedPD28560854
PA162263534OtotoxicityDiseaseClinicalAnnotationassociatedPD19898482, 23588304, 23820299, 24642735, 25141953, 25551397, 28445188, 28448657
PA164712362AnalgesicsChemicalClinicalAnnotationassociated25096645
PA164712462Antiinflammatory agents, non-steroidsChemicalClinicalAnnotationassociated25096645
PA164712720Drugs used in nicotine dependenceChemicalVariantAnnotationassociatedPD26555332
PA164712741Ergot alkaloidsChemicalClinicalAnnotationassociated25096645
PA164712898MethyldopaChemicalVipGeneassociated
PA164713257Selective serotonin reuptake inhibitorsChemicalClinicalAnnotation, Literature, MultilinkAnnotationassociatedPD24930681
PA164747026trihexyphenidylChemicalVipGeneassociated
PA164748726entacaponeChemicalClinicalAnnotationassociatedPD21280081
PA166119022methamphetamine dependenceDiseaseClinicalAnnotationassociatedPD
PA166123046cessationDiseaseVariantAnnotationassociatedPD26555332
PA166131303etoposide catecholChemicalVipGeneassociated
PA166151827adverse eventsDiseaseClinicalAnnotationassociatedPD30549211
PA166156024rs4680VariantVipGeneassociated10963624, 11150892, 11401913, 11434504, 11525417, 11990384, 12372660, 12729939, 12815736, 14520117, 14575568, 14610521, 14637391, 15098000, 15115916, 15124004, 15388245, 15455371, 15465976, 15522252, 15538046, 15645182, 16191465, 16421368, 16702905, 8725388, 9407957, 9535125, 9605753, 9855007, 10519398
PA166185626somnolenceDiseaseClinicalAnnotationassociatedPD30281924
PA443560Breast NeoplasmsDiseaseVipGeneassociated10963624, 11401913, 11434504, 14575568, 14637391, 15098000, 15124004, 15388245, 15455371, 15538046, 15645182, 16191465, 16421368, 8725388, 9407957, 9605753, 9855007, 10519398
PA443842DeathDiseaseClinicalAnnotationassociatedPD27061230
PA443928DizzinessDiseaseClinicalAnnotationassociatedPD31745220
PA443937Drug ToxicityDiseaseClinicalAnnotationassociatedPD19898482, 23588304, 23820299, 24642735, 25141953, 25551397, 28445188, 28448657
PA444510HyperalgesiaDiseaseClinicalAnnotationassociatedPD
PA445042NarcolepsyDiseaseVipGeneassociated11990384, 12359690, 12465073, 12605099, 15956988, 9352569, 9631418, 11840516
PA445043Opioid-Related DisordersDiseaseClinicalAnnotation, VipGeneassociatedPD12595695, 15098000, 15124004, 15645182, 15927391, 16421368, 8725388, 9259381, 11054766, 27061230, 30549211, 32407152
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPD19898482, 23588304, 23820299, 24642735, 25141953, 25551397, 28445188, 28448657, 28560854
PA445208PainDiseaseClinicalAnnotation, VipGeneassociatedPD19514130, 21398039, 23302985, 23686330, 23773341, 24533707, 25155931, 25185591, 26902643, 27027462, 28006928, 28745577, 29474345
PA445254Parkinson DiseaseDiseaseClinicalAnnotation, Literature, MultilinkAnnotation, VipGeneassociatedPD11990384, 12359690, 12465073, 12605099, 15956988, 9352569, 9631418, 11840516, 21280081, 24819480
PA445876Tobacco Use DisorderDiseaseClinicalAnnotation, VipGeneassociatedPD12595695, 15927391, 9259381, 11054766, 11927842, 16395295, 16876132, 18192898, 22695756, 26555332
PA446444Low Back PainDiseaseClinicalAnnotationassociatedPD19514130, 21398039, 23302985, 23686330, 23773341, 25155931, 25185591, 26902643, 27027462, 28006928, 28745577, 29474345
PA447196Anxiety DisordersDiseaseClinicalAnnotation, VipGeneassociatedPD11990384, 12359690, 12465073, 12605099, 15956988, 9352569, 9631418, 11840516, 22417933, 23706899, 28627776
PA447197Attention Deficit Disorder with HyperactivityDiseaseClinicalAnnotationassociatedPD18214865, 18703939, 21550019, 22149470, 23131881, 24035255, 24763183, 29230023
PA447199Bipolar DisorderDiseaseVipGeneassociated11990384, 12359690, 12465073, 12605099, 15956988, 9352569, 9631418, 11840516
PA447207Depressive DisorderDiseaseClinicalAnnotation, VipGeneassociatedPD11990384, 12359690, 12465073, 12605099, 15956988, 9352569, 9631418, 11840516, 22417933, 23706899, 28627776
PA447211Obsessive-Compulsive DisorderDiseaseVipGeneassociated11990384, 12359690, 12465073, 12605099, 15956988, 9352569, 9631418, 11840516
PA447212Panic DisorderDiseaseVipGeneassociated11990384, 12359690, 12465073, 12605099, 15956988, 9352569, 9631418, 11840516
PA447216SchizophreniaDiseaseClinicalAnnotation, VipGeneassociatedPD11525417, 11990384, 12372660, 12729939, 12815736, 14520117, 14610521, 15098000, 15115916, 15124004, 15465976, 15522252, 15645182, 16421368, 16702905, 8725388, 9535125, 11150892, 19451915, 22391769, 22935916, 23963056, 25560469, 26282453
PA447218Sexual Dysfunctions, PsychologicalDiseaseClinicalAnnotationassociatedPD31745220
PA447268tardive dyskinesiaDiseaseClinicalAnnotationassociatedPD18180754
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotationassociatedPD18989660, 20619611
PA448591benztropineChemicalVipGeneassociated
PA448685buprenorphineChemicalClinicalAnnotationassociatedPD30549211
PA448687bupropionChemicalClinicalAnnotationassociatedPD16876132
PA449014cisplatinChemicalClinicalAnnotationassociatedPD19898482, 23588304, 23820299, 24642735, 25141953, 25551397, 28445188, 28448657, 28560854
PA449061clozapineChemicalClinicalAnnotationassociatedPD25560469
PA449599fentanylChemicalClinicalAnnotationassociatedPD30281924, 30549211
PA449690fluvoxamineChemicalClinicalAnnotationassociatedPD20619611
PA449841haloperidolChemicalClinicalAnnotation, MultilinkAnnotation, VipGeneassociatedPD23963056, 27023437
PA450213levodopaChemicalVipGeneassociated
PA450243lithiumChemicalVipGeneassociated
PA450401methadoneChemicalClinicalAnnotationassociatedPD19514130, 21398039, 23302985, 23686330, 23773341, 25155931, 25185591, 26902643, 27027462, 28006928, 28745577, 29474345, 32407152
PA450464methylphenidateChemicalClinicalAnnotationassociatedPD18214865, 18703939, 21550019, 22149470, 23131881, 24035255, 24763183, 29230023
PA450530modafinilChemicalClinicalAnnotation, VipGeneassociatedPD11990384, 12359690, 12465073, 12605099, 15956988, 9352569, 9631418, 11840516
PA450550morphineChemicalClinicalAnnotation, VipGeneassociatedPD12595695, 15927391, 9259381, 11054766, 19514130, 21398039, 23302985, 23686330, 23773341, 25155931, 25185591, 26902643, 27027462, 28006928, 28745577, 29474345
PA450626nicotineChemicalClinicalAnnotationassociatedPD11927842, 16395295, 18192898, 22695756, 26555332
PA450649norepinephrineChemicalVipGeneassociated
PA450688olanzapineChemicalVipGeneassociated
PA450741oxycodoneChemicalClinicalAnnotationassociatedPD19514130, 21398039, 23302985, 23686330, 23773341, 25155931, 25185591, 26902643, 27027462, 28006928, 28745577, 29474345
PA450801paroxetineChemicalClinicalAnnotation, VipGeneassociatedPD18989660
PA451201quetiapineChemicalClinicalAnnotation, VipGeneassociatedPD26282453
PA451232remifentanilChemicalClinicalAnnotationassociatedPD19514130, 21398039, 23302985, 23686330, 23773341, 25155931, 25185591, 26902643, 27027462, 28006928, 28745577, 29474345
PA451257risperidoneChemicalClinicalAnnotation, VipGeneassociatedPD19451915, 22935916
PA451333sertralineChemicalVipGeneassociated
PA451527sufentanilChemicalClinicalAnnotationassociatedPD19514130, 21398039, 23302985, 23686330, 23773341, 25155931, 25185591, 26902643, 27027462, 28006928, 28745577, 29474345
PA451566sumatriptanChemicalClinicalAnnotationassociated25096645
PA451735tramadolChemicalClinicalAnnotation, Literature, MultilinkAnnotationambiguousPD19514130, 21398039, 23302985, 23686330, 23773341, 24624916, 25155931, 25185591, 26902643, 27027462, 28006928, 28745577, 29474345, 30549211
PA451846valproic acidChemicalVipGeneassociated
PA451866venlafaxineChemicalClinicalAnnotationassociatedPD22417933, 23706899, 28627776
PA452233antipsychoticsChemicalClinicalAnnotation, VipGeneassociatedPD11525417, 11990384, 12372660, 12729939, 12815736, 14520117, 14610521, 15115916, 15465976, 15522252, 16702905, 9535125, 11150892, 18180754, 22391769, 25048416
PA452618opioidsChemicalClinicalAnnotationassociatedPD19514130, 21398039, 23302985, 23686330, 23773341, 24533707, 25096645, 25155931, 25185591, 26902643, 27027462, 27061230, 28006928, 28745577, 29474345, 31745220
PA452619heroinChemicalVipGeneassociated

References

Pubmed IDYearTitleCitations
380433622024The association of gene polymorphisms in catechol-O'methyltransferase (COMT) and β2-adrenergic receptor (ADRB2) with temporomandibular joint disorders.1
381427232024Associations between Catechol-O-methyltransferase (COMT) polymorphisms and cognitive impairments, psychiatric symptoms and tardive dyskinesia in schizophrenia.0
381983692024Dental pain report in children and genetic polymorphism (rs4818) in Catechol-O-Methyltransferase (COMT) gene: a cross- sectional study.0
382281182024To Each His Own Fear: Gender-Related Association of Anxiety, Substance Use, and Eating Disorders in a Representative Birth Cohort Sample of Young Adults with Either COMT Val158Met allele.0
382442772024Catechol-O-methyltransferase gene (COMT) is associated with neurocognitive functioning in patients with sickle cell disease.0
383295872024COMT and SCN9A gene variants do not contribute to chronic low back pain in Mexican-Mestizo patients.0
384039422024Effects of functional polymorphisms of opioid receptor mu 1 and catechol-O-methyltransferase on the neural processing of pain.0
384086402024Moderating effects of preoperative knee pain and pain catastrophizing on the relation between COMT rs4680 genotypes and chronic postsurgical pain in total knee arthroplasty patients.0
384614562024Preliminary Evidence for a Positive Relation Between the COMT rs4680 Met/Met Genotype and Math Achievement.0
385403582024The Influence of Genetic Polymorphic Variability of the Catechol-O-methyltransferase Gene in a Group of Patients with a Diagnosis of Behavioural Addiction, including Personality Traits.0
386890062024Longitudinal study investigating the influence of COMT gene polymorphism on cortical thickness changes in Parkinson's disease over four years.0
387396202024Association between executive functions and COMT Val108/158Met polymorphism among healthy younger and older adults: A preliminary study.0
388615732024Association of catechol-o-methyltransferase gene polymorphism with preeclampsia and biomarkers of oxidative stress: Study protocol for a prospective case-control study in Pakistan.0
380433622024The association of gene polymorphisms in catechol-O'methyltransferase (COMT) and β2-adrenergic receptor (ADRB2) with temporomandibular joint disorders.1
381427232024Associations between Catechol-O-methyltransferase (COMT) polymorphisms and cognitive impairments, psychiatric symptoms and tardive dyskinesia in schizophrenia.0

Citation

Dessen P

COMT (catechol-O-methyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40130/comt