COP1 (COP1 E3 ubiquitin ligase)

2018-02-01  

Identity

HGNC
COP1
LOCATION
1q25.1
LOCUSID
64326
ALIAS
CFAP78,FAP78,RFWD2,RNF200

Other Information

Locus ID:

NCBI: 64326
MIM: 608067
HGNC: 17440
Ensembl: ENSG00000143207

Variants:

dbSNP: 64326
ClinVar: 64326
TCGA: ENSG00000143207
COSMIC: COP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143207ENST00000308769Q8NHY2
ENSG00000143207ENST00000367666H0Y339
ENSG00000143207ENST00000367667H0Y340
ENSG00000143207ENST00000367669Q8NHY2
ENSG00000143207ENST00000459744H0YF49
ENSG00000143207ENST00000474194Q8NHY2
ENSG00000143207ENST00000491600E9PMW8
ENSG00000143207ENST00000498306E9PJB5
ENSG00000143207ENST00000649803A0A3B3ISQ9

Pathways

PathwaySourceExternal ID
p53 signaling pathwayKEGGko04115
Ubiquitin mediated proteolysisKEGGko04120
p53 signaling pathwayKEGGhsa04115
Ubiquitin mediated proteolysisKEGGhsa04120
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G1/S DNA Damage CheckpointsREACTOMER-HSA-69615
p53-Dependent G1/S DNA damage checkpointREACTOMER-HSA-69580
p53-Dependent G1 DNA Damage ResponseREACTOMER-HSA-69563
Stabilization of p53REACTOMER-HSA-69541
Autodegradation of the E3 ubiquitin ligase COP1REACTOMER-HSA-349425

References

Pubmed IDYearTitleCitations
370250972023Effect of COP1 in Promoting the Tumorigenesis of Gastric Cancer by Down-Regulation of CDH18 via PI3K/AKT Signal Pathway.3
377001602023Constitutive photomorphogenic protein 1 ubiquitinates interleukin-1 receptor accessory protein in human liver cancer.0
370250972023Effect of COP1 in Promoting the Tumorigenesis of Gastric Cancer by Down-Regulation of CDH18 via PI3K/AKT Signal Pathway.3
377001602023Constitutive photomorphogenic protein 1 ubiquitinates interleukin-1 receptor accessory protein in human liver cancer.0
350846532022COP1 Acts as a Ubiquitin Ligase for PCDH9 Ubiquitination and Degradation in Human Glioma.2
362519942022A COP1-GATA2 axis suppresses AR signaling and prostate cancer.5
350846532022COP1 Acts as a Ubiquitin Ligase for PCDH9 Ubiquitination and Degradation in Human Glioma.2
362519942022A COP1-GATA2 axis suppresses AR signaling and prostate cancer.5
329011002021RFWD2 induces cellular proliferation and selective proteasome inhibitor resistance by mediating P27 ubiquitination in multiple myeloma.5
329011002021RFWD2 induces cellular proliferation and selective proteasome inhibitor resistance by mediating P27 ubiquitination in multiple myeloma.5
320279782020Role of the COP1 protein in cancer development and therapy.12
327954152020Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia.44
320279782020Role of the COP1 protein in cancer development and therapy.12
327954152020Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia.44
309261712019PEDF promotes nuclear degradation of ATGL through COP1.10

Citation

Dessen P

COP1 (COP1 E3 ubiquitin ligase)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57360/cop1