Identity
HGNC
LOCATION
7q22.1
LOCUSID
ALIAS
CSN6,MOV34-34KD
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10980
MIM: 614729
HGNC: 21749
Ensembl: ENSG00000168090
Variants:
dbSNP: 10980
ClinVar: 10980
TCGA: ENSG00000168090
COSMIC: COPS6
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000168090 | ENST00000303904 | Q7L5N1 |
| ENSG00000168090 | ENST00000418625 | E7EM64 |
| ENSG00000168090 | ENST00000419210 | C9JQK5 |
| ENSG00000168090 | ENST00000426712 | H7C3T0 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38308184 | 2024 | CSN6-SPOP-HMGCS1 Axis Promotes Hepatocellular Carcinoma Progression via YAP1 Activation. | 5 |
| 38308184 | 2024 | CSN6-SPOP-HMGCS1 Axis Promotes Hepatocellular Carcinoma Progression via YAP1 Activation. | 5 |
| 36512632 | 2023 | CSN6 Mediates Nucleotide Metabolism to Promote Tumor Development and Chemoresistance in Colorectal Cancer. | 10 |
| 36512632 | 2023 | CSN6 Mediates Nucleotide Metabolism to Promote Tumor Development and Chemoresistance in Colorectal Cancer. | 10 |
| 33179082 | 2021 | CUL4A regulates endometrial cancer cell proliferation, invasion and migration by interacting with CSN6. | 6 |
| 33483464 | 2021 | CSN6 promotes melanoma proliferation and metastasis by controlling the UBR5-mediated ubiquitination and degradation of CDK9. | 11 |
| 33179082 | 2021 | CUL4A regulates endometrial cancer cell proliferation, invasion and migration by interacting with CSN6. | 6 |
| 33483464 | 2021 | CSN6 promotes melanoma proliferation and metastasis by controlling the UBR5-mediated ubiquitination and degradation of CDK9. | 11 |
| 31422034 | 2020 | Overexpression of CSN6 promotes the epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma. | 7 |
| 32134157 | 2020 | EGFR-ERK pathway regulates CSN6 to contribute to PD-L1 expression in glioblastoma. | 24 |
| 32225170 | 2020 | CSN6-TRIM21 axis instigates cancer stemness during tumorigenesis. | 15 |
| 32289284 | 2020 | CSN6 inhibition suppresses pancreatic adenocarcinoma metastasis via destabilizing the c-Fos protein. | 4 |
| 32495877 | 2020 | CSN6 promotes malignant progression of oral squamous cell carcinoma by down-regulating TIMP-2. | 3 |
| 33162808 | 2020 | CSN6 promotes the cell migration of breast cancer cells by positively regulating Snail1 stability. | 4 |
| 31422034 | 2020 | Overexpression of CSN6 promotes the epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma. | 7 |
Citation
Dessen P
COPS6 (COP9 signalosome subunit 6)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/47367/cops6
