CORO1A (coronin 1A)

2012-01-01  

Identity

HGNC
LOCATION
16p11.2
LOCUSID
ALIAS
CLABP,CLIPINA,HCORO1,IMD8,TACO,p57

Other Information

Locus ID:

NCBI: 11151
MIM: 605000
HGNC: 2252
Ensembl: ENSG00000102879

Variants:

dbSNP: 11151
ClinVar: 11151
TCGA: ENSG00000102879
COSMIC: CORO1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102879ENST00000219150P31146
ENSG00000102879ENST00000219150A0A024R611
ENSG00000102879ENST00000561815H3BSL1
ENSG00000102879ENST00000563778H3BRJ0
ENSG00000102879ENST00000565497H3BRY3
ENSG00000102879ENST00000569203H3BNA2
ENSG00000102879ENST00000569970H3BU76
ENSG00000102879ENST00000570045P31146
ENSG00000102879ENST00000570045A0A024R611
ENSG00000102879ENST00000570244H3BTU6

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900

Pathways

PathwaySourceExternal ID
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
188364492008The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency.76
158000612005Association of the leukocyte plasma membrane with the actin cytoskeleton through coiled coil-mediated trimeric coronin 1 molecules.39
235224822013Whole-exome sequencing identifies Coronin-1A deficiency in 3 siblings with immunodeficiency and EBV-associated B-cell lymphoproliferation.38
247608282014Lytic immune synapse function requires filamentous actin deconstruction by Coronin 1A.32
218739802011Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation.28
194547222009Coronin-1 is associated with neutrophil survival and is cleaved during apoptosis: potential implication in neutrophils from cystic fibrosis patients.21
174429612007Coronin function is required for chemotaxis and phagocytosis in human neutrophils.20
250735072014Compound heterozygous CORO1A mutations in siblings with a mucocutaneous-immunodeficiency syndrome of epidermodysplasia verruciformis-HPV, molluscum contagiosum and granulomatous tuberculoid leprosy.17
213393622011Migration and homeostasis of naive T cells depends on coronin 1-mediated prosurvival signals and not on coronin 1-dependent filamentous actin modulation.15
156012632005Homotypic dimerization of the actin-binding protein p57/coronin-1 mediated by a leucine zipper motif in the C-terminal region.12

Citation

Dessen P

CORO1A (coronin 1A)

Atlas Genet Cytogenet Oncol Haematol. 2012-01-01

Online version: http://atlasgeneticsoncology.org/gene/52535/coro1a