COX16 (cytochrome c oxidase assembly factor COX16)

2014-11-01 Affiliation

Identity

HGNC

COX16

LOCATION

14q24.2

LOCUSID

51241

ALIAS

C14orf112,HSPC203,MC4DN22,hCOX16

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 51241
MIM: 618064
HGNC: 20213
Ensembl: ENSG00000133983

Variants:

dbSNP: 51241
ClinVar: 51241
TCGA: ENSG00000133983
COSMIC: COX16

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000133983	ENST00000389912	Q9P0S2
ENSG00000133983	ENST00000555276	A0A087WX56

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
TP53 Regulates Metabolic Genes	REACTOME	R-HSA-5628897
Metabolism	REACTOME	R-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transport	REACTOME	R-HSA-1428517
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	REACTOME	R-HSA-163200
Respiratory electron transport	REACTOME	R-HSA-611105

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20877624	2010	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	17
29381136	2018	COX16 promotes COX2 metallation and assembly during respiratory complex IV biogenesis.	9
29355485	2018	COX16 is required for assembly of cytochrome c oxidase in human cells and is involved in copper delivery to COX2.	5

Citation

Dessen P

COX16 (cytochrome c oxidase assembly factor COX16)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62038/cox16