COX5B (cytochrome c oxidase subunit 5B)

2007-04-01 Affiliation

Identity

HGNC

COX5B

LOCATION

2q11.2

LOCUSID

1329

ALIAS

COXVB

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1329
MIM: 123866
HGNC: 2269
Ensembl: ENSG00000135940

Variants:

dbSNP: 1329
ClinVar: 1329
TCGA: ENSG00000135940
COSMIC: COX5B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000135940	ENST00000258424	P10606
ENSG00000135940	ENST00000258424	A0A384NL93

Expression (GTEx)

100

150

200

250

300

350

400

450

500

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Oxidative phosphorylation	KEGG	ko00190
Alzheimer's disease	KEGG	ko05010
Huntington's disease	KEGG	ko05016
Oxidative phosphorylation	KEGG	hsa00190
Alzheimer's disease	KEGG	hsa05010
Parkinson's disease	KEGG	hsa05012
Huntington's disease	KEGG	hsa05016
Cardiac muscle contraction	KEGG	hsa04260
Cardiac muscle contraction	KEGG	ko04260
Metabolic pathways	KEGG	hsa01100
Cytochrome c oxidase	KEGG	hsa_M00154
Cytochrome c oxidase	KEGG	M00154
Non-alcoholic fatty liver disease (NAFLD)	KEGG	hsa04932
Non-alcoholic fatty liver disease (NAFLD)	KEGG	ko04932
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
TP53 Regulates Metabolic Genes	REACTOME	R-HSA-5628897
Metabolism	REACTOME	R-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transport	REACTOME	R-HSA-1428517
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	REACTOME	R-HSA-163200
Respiratory electron transport	REACTOME	R-HSA-611105

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19834492	2010	Involvement of cytochrome c oxidase subunits Va and Vb in the regulation of cancer cell metabolism by Bcl-2.	44
20877624	2010	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	17
20198315	2010	Association of genetic variants with hemorrhagic stroke in Japanese individuals.	11
22917272	2012	Cytochrome c oxidase is activated by the oncoprotein Ras and is required for A549 lung adenocarcinoma growth.	8
26506233	2015	Loss of COX5B inhibits proliferation and promotes senescence via mitochondrial dysfunction in breast cancer.	4
19851296	2010	Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.	3
28592145	2017	High expression of COX5B is associated with poor prognosis in breast cancer.	1
29111436	2018	Topography of human cytochrome b<sub>5</sub>/cytochrome b<sub>5</sub> reductase interacting domain and redox alterations upon complex formation.	1

Citation

Dessen P

COX5B (cytochrome c oxidase subunit 5B)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47189/cox5b