CPD (carboxypeptidase D)

2007-02-01  

Identity

HGNC
CPD
LOCATION
17q11.2
LOCUSID
1362
ALIAS
GP180
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1362
MIM: 603102
HGNC: 2301
Ensembl: ENSG00000108582

Variants:

dbSNP: 1362
ClinVar: 1362
TCGA: ENSG00000108582
COSMIC: CPD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108582ENST00000225719O75976
ENSG00000108582ENST00000543464O75976
ENSG00000108582ENST00000579502J3QRJ9
ENSG00000108582ENST00000584050K7ELF0
ENSG00000108582ENST00000584221J3QQJ4

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
trans-Golgi Network Vesicle BuddingREACTOMER-HSA-199992
Clathrin derived vesicle buddingREACTOMER-HSA-421837
Golgi Associated Vesicle BiogenesisREACTOMER-HSA-432722

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
185351092008Prolactin and estrogen up-regulate carboxypeptidase-d to promote nitric oxide production and survival of mcf-7 breast cancer cells.10
252948782014Amyloid formation by human carboxypeptidase D transthyretin-like domain under physiological conditions.9
113067182001Carboxypeptidase D is up-regulated in raw 264.7 macrophages and stimulates nitric oxide synthesis by cells in arginine-free medium.6
126432882003Palmitoylation of carboxypeptidase D. Implications for intracellular trafficking.6
274947422016microRNA-214 Governs Lung Cancer Growth and Metastasis by Targeting Carboxypeptidase-D.6
246157302014Carboxypeptidase-D is elevated in prostate cancer and its anti-apoptotic activity is abolished by combined androgen and prolactin receptor targeting.4
283642162017Prolactin/androgen-inducible carboxypeptidase-D increases with nitrotyrosine and Ki67 for breast cancer progression in vivo, and upregulates progression markers VEGF-C and Runx2 in vitro.3
159187962005Characterization of a novel, cytokine-inducible carboxypeptidase D isoform in haematopoietic tumour cells.2
176419572007Carboxypeptidase D: a novel TGF-beta target gene dysregulated in patients with lupus erythematosus.2
216289992011Differential regulation and localization of carboxypeptidase D and carboxypeptidase E in human and mouse β-cells.2

Citation

Dessen P

CPD (carboxypeptidase D)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46417/cpd