CPE (carboxypeptidase E)

2007-02-01  

Identity

HGNC
CPE
LOCATION
4q32.3
LOCUSID
1363
ALIAS
CPH,IDDHH
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1363
MIM: 114855
HGNC: 2303
Ensembl: ENSG00000109472

Variants:

dbSNP: 1363
ClinVar: 1363
TCGA: ENSG00000109472
COSMIC: CPE

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109472ENST00000402744P16870
ENSG00000109472ENST00000402744A0A384N679
ENSG00000109472ENST00000431967C9JE88
ENSG00000109472ENST00000480404H0YAM0
ENSG00000109472ENST00000511992D6R930
ENSG00000109472ENST00000513982D6RF88

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Type I diabetes mellitusKEGGko04940
Type I diabetes mellitusKEGGhsa04940
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Insulin processingREACTOMER-HSA-264876

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
202019242010Genome-wide association study of alcohol dependence implicates a region on chromosome 11.159
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
185508192008Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis.57
114622362001Missense polymorphism in the human carboxypeptidase E gene alters enzymatic activity.33
154929862004Identification of carboxypeptidase E and gamma-glutamyl hydrolase as biomarkers for pulmonary neuroendocrine tumors by cDNA microarray.30
204680642010Association study of 182 candidate genes in anorexia nervosa.30
125305262002Carboxypeptidase E and thrombospondin-1 are differently expressed in subcutaneous and visceral fat of obese subjects.20
228247912013Carboxypeptidase E: a negative regulator of the canonical Wnt signaling pathway.18
195932122009Novel genetic variants contributing to left ventricular hypertrophy: the HyperGEN study.17

Citation

Dessen P

CPE (carboxypeptidase E)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43589/cpe