CPE (carboxypeptidase E)

2007-02-01  

Identity

HGNC
LOCATION
4q32.3
LOCUSID
ALIAS
CPH,IDDHH
FUSION GENES

Other Information

Locus ID:

NCBI: 1363
MIM: 114855
HGNC: 2303
Ensembl: ENSG00000109472

Variants:

dbSNP: 1363
ClinVar: 1363
TCGA: ENSG00000109472
COSMIC: CPE

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109472ENST00000402744P16870
ENSG00000109472ENST00000402744A0A384N679
ENSG00000109472ENST00000431967C9JE88
ENSG00000109472ENST00000480404H0YAM0
ENSG00000109472ENST00000511992D6R930
ENSG00000109472ENST00000513982D6RF88

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900

Pathways

PathwaySourceExternal ID
Type I diabetes mellitusKEGGko04940
Type I diabetes mellitusKEGGhsa04940
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Insulin processingREACTOMER-HSA-264876

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
371007792023Carboxypeptidase E conditional knockout mice exhibit learning and memory deficits and neurodegeneration.1
371007792023Carboxypeptidase E conditional knockout mice exhibit learning and memory deficits and neurodegeneration.1
345114862022Carboxypeptidase E mRNA: Overexpression predicts recurrence and death in lung adenocarcinoma cancer patients.3
345114862022Carboxypeptidase E mRNA: Overexpression predicts recurrence and death in lung adenocarcinoma cancer patients.3
340296972021In silico analysis of non-synonymous missense SNPs (nsSNPs) in CPE, GNAS genes and experimental validation in type II diabetes mellitus through Next Generation Sequencing.2
343830792021BDV Syndrome: An Emerging Syndrome With Profound Obesity and Neurodevelopmental Delay Resembling Prader-Willi Syndrome.7
349669482021Novel interaction between neurotrophic factor-α1/carboxypeptidase E and serotonin receptor, 5-HTR1E, protects human neurons against oxidative/neuroexcitotoxic stress via β-arrestin/ERK signaling.14
355289562021Silencing of Carboxypeptidase E expression inhibits proliferation and invasion of Panc-1 pancreatic cancer cells.4
340296972021In silico analysis of non-synonymous missense SNPs (nsSNPs) in CPE, GNAS genes and experimental validation in type II diabetes mellitus through Next Generation Sequencing.2
343830792021BDV Syndrome: An Emerging Syndrome With Profound Obesity and Neurodevelopmental Delay Resembling Prader-Willi Syndrome.7
349669482021Novel interaction between neurotrophic factor-α1/carboxypeptidase E and serotonin receptor, 5-HTR1E, protects human neurons against oxidative/neuroexcitotoxic stress via β-arrestin/ERK signaling.14
355289562021Silencing of Carboxypeptidase E expression inhibits proliferation and invasion of Panc-1 pancreatic cancer cells.4
326753942020Carboxypeptidase E down-regulation regulates transcriptional and epigenetic profiles in pancreatic cancer cell line: A network analysis.5
326753942020Carboxypeptidase E down-regulation regulates transcriptional and epigenetic profiles in pancreatic cancer cell line: A network analysis.5
281143322017A Novel Single Nucleotide T980C Polymorphism in the Human Carboxypeptidase E Gene Results in Loss of Neuroprotective Function.5

Citation

Dessen P

CPE (carboxypeptidase E)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43589/cpe