CPEB3 (cytoplasmic polyadenylation element binding protein 3)

2016-12-01  

Identity

HGNC
CPEB3
LOCATION
10q23.32
LOCUSID
22849
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 22849
MIM: 610606
HGNC: 21746
Ensembl: ENSG00000107864

Variants:

dbSNP: 22849
ClinVar: 22849
TCGA: ENSG00000107864
COSMIC: CPEB3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107864ENST00000265997Q8NE35
ENSG00000107864ENST00000412050Q8NE35
ENSG00000107864ENST00000412050Q5QP71
ENSG00000107864ENST00000614585Q8NE35

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Dorso-ventral axis formationKEGGko04320
Progesterone-mediated oocyte maturationKEGGko04914
Dorso-ventral axis formationKEGGhsa04320
Progesterone-mediated oocyte maturationKEGGhsa04914
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114

References

Pubmed IDYearTitleCitations
169905492006A genomewide search for ribozymes reveals an HDV-like sequence in the human CPEB3 gene.111
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
213362572011Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase.27
195037532009CPEB3 is associated with human episodic memory.17
264975562016MicroRNA-107: a novel promoter of tumor progression that targets the CPEB3/EGFR axis in human hepatocellular carcinoma.17
227119862012Calpain 2 activated through N-methyl-D-aspartic acid receptor signaling cleaves CPEB3 and abrogates CPEB3-repressed translation in neurons.16
205246722010The human HDV-like CPEB3 ribozyme is intrinsically fast-reacting.13
275150062016MicroRNA and target gene expression based clustering of oral cancer, precancer and normal tissues.8
293324492017Mir-452-3p: A Potential Tumor Promoter That Targets the CPEB3/EGFR Axis in Human Hepatocellular Carcinoma.5

Citation

Dessen P

CPEB3 (cytoplasmic polyadenylation element binding protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2016-12-01

Online version: http://atlasgeneticsoncology.org/gene/56632/cpeb3