CPNE1 (copine 1)

Identity

HGNC

CPNE1

LOCATION

20q11.22

LOCUSID

8904

ALIAS

COPN1,CPN1

FUSION GENES

Show Gene Fusions

Other Information

Locus ID:

NCBI: 8904
MIM: 604205
HGNC: 2314
Ensembl: ENSG00000214078

Variants:

dbSNP: 8904
ClinVar: 8904
TCGA: ENSG00000214078
COSMIC: CPNE1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000214078	ENST00000317677	B0QZ18
ENSG00000214078	ENST00000352393	Q99829
ENSG00000214078	ENST00000397442	A6PVH9
ENSG00000214078	ENST00000397443	Q99829
ENSG00000214078	ENST00000401607	E7ENH5
ENSG00000214078	ENST00000412056	Q5JX52
ENSG00000214078	ENST00000414664	Q5JX44
ENSG00000214078	ENST00000414711	Q5JX54
ENSG00000214078	ENST00000415920	H0Y524
ENSG00000214078	ENST00000416778	Q5JX61
ENSG00000214078	ENST00000420363	Q5JX59
ENSG00000214078	ENST00000430570	Q5JX45
ENSG00000214078	ENST00000434795	Q5JX58
ENSG00000214078	ENST00000435747	Q5JX53
ENSG00000214078	ENST00000437100	Q5JX55
ENSG00000214078	ENST00000437340	F2Z2V0
ENSG00000214078	ENST00000439669	E7EV27
ENSG00000214078	ENST00000439806	Q5JX60
ENSG00000214078	ENST00000440240	Q5JX56
ENSG00000214078	ENST00000458038	Q5JX57

Expression (GTEx)

0

50

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Phospholipid metabolism	REACTOME	R-HSA-1483257
Glycerophospholipid biosynthesis	REACTOME	R-HSA-1483206
Neutrophil degranulation	REACTOME	R-HSA-6798695

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
14674885	2004	Calcium-dependent regulation of tumour necrosis factor-alpha receptor signalling by copine.	17
29970127	2018	CPNE1 is a target of miR-335-5p and plays an important role in the pathogenesis of non-small cell lung cancer.	13
18831769	2008	Promoter-sharing by different genes in human genome--CPNE1 and RBM12 gene pair as an example.	6
29151113	2017	CPNE1 Is a Useful Prognostic Marker and Is Associated with TNF Receptor-Associated Factor 2 (TRAF2) Expression in Prostate Cancer.	6
18523666	2008	Upregulation of Copine1 in trabecular meshwork cells of POAG patients: a membrane proteomics approach.	3
29207139	2018	CPNE1 silencing inhibits the proliferation, invasion and migration of human osteosarcoma cells.	3
30221693	2018	High expression of Copine 1 promotes cell growth and metastasis in human lung adenocarcinoma.	3
29448099	2018	JAB1 regulates CPNE1-related differentiation via direct binding to CPNE1 in HiB5 hippocampal progenitor cells.	1

Citation

Dessen P

CPNE1 (copine 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45925/cpne1