Identity
HGNC
LOCATION
2p25.1
LOCUSID
ALIAS
CPSF-73,CPSF73
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 51692
MIM: 606029
HGNC: 2326
Ensembl: ENSG00000119203
Variants:
dbSNP: 51692
ClinVar: 51692
TCGA: ENSG00000119203
COSMIC: CPSF3
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000119203 | ENST00000238112 | Q9UKF6 |
| ENSG00000119203 | ENST00000460593 | G5E9W3 |
| ENSG00000119203 | ENST00000475482 | C9JZH6 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38191171 | 2024 | CPSF3 inhibition blocks pancreatic cancer cell proliferation through disruption of core histone mRNA processing. | 0 |
| 38718887 | 2024 | CPSF3 regulates alternative polyadenylation of CNIH2 to promote esophageal squamous cell carcinoma progression. | 0 |
| 38191171 | 2024 | CPSF3 inhibition blocks pancreatic cancer cell proliferation through disruption of core histone mRNA processing. | 0 |
| 38718887 | 2024 | CPSF3 regulates alternative polyadenylation of CNIH2 to promote esophageal squamous cell carcinoma progression. | 0 |
| 36822327 | 2023 | An examination of the metal ion content in the active sites of human endonucleases CPSF73 and INTS11. | 2 |
| 37992178 | 2023 | Therapeutic targeting of CPSF3-dependent transcriptional termination in ovarian cancer. | 1 |
| 36822327 | 2023 | An examination of the metal ion content in the active sites of human endonucleases CPSF73 and INTS11. | 2 |
| 37992178 | 2023 | Therapeutic targeting of CPSF3-dependent transcriptional termination in ovarian cancer. | 1 |
| 35121750 | 2022 | Population-level deficit of homozygosity unveils CPSF3 as an intellectual disability syndrome gene. | 5 |
| 35121750 | 2022 | Population-level deficit of homozygosity unveils CPSF3 as an intellectual disability syndrome gene. | 5 |
| 33666519 | 2021 | Cleavage and polyadenylation-specific factor 3 induces cell cycle arrest via PI3K/Akt/GSK-3β signaling pathways and predicts a negative prognosis in hepatocellular carcinoma. | 2 |
| 34230059 | 2021 | A real-time fluorescence assay for CPSF73, the nuclease for pre-mRNA 3'-end processing. | 5 |
| 33666519 | 2021 | Cleavage and polyadenylation-specific factor 3 induces cell cycle arrest via PI3K/Akt/GSK-3β signaling pathways and predicts a negative prognosis in hepatocellular carcinoma. | 2 |
| 34230059 | 2021 | A real-time fluorescence assay for CPSF73, the nuclease for pre-mRNA 3'-end processing. | 5 |
| 31819276 | 2020 | CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma. | 32 |
Citation
Dessen P
CPSF3 (cleavage and polyadenylation specific factor 3)
Atlas Genet Cytogenet Oncol Haematol. 2009-03-01
Online version: http://atlasgeneticsoncology.org/gene/50692/cpsf3
