Identity
HGNC
LOCATION
1q32.2
LOCUSID
ALIAS
C3BR,C4BR,CD35,KN
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1378
MIM: 120620
HGNC: 2334
Ensembl: ENSG00000203710
Variants:
dbSNP: 1378
ClinVar: 1378
TCGA: ENSG00000203710
COSMIC: CR1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164776637 | eculizumab | Chemical | ClinicalAnnotation | associated | PD | 24038027 | |
| PA166122772 | paroxysmal nocturnal hemoglobinuria | Disease | ClinicalAnnotation | associated | PD | 24038027 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36626386 | 2023 | Population-specific positive selection on low CR1 expression in malaria-endemic regions. | 0 |
| 36924837 | 2023 | Genetic variant in complement receptor 1 (CR1, CD35) is associated with a cluster of severe fatal COVID-19 in a family. | 1 |
| 37591894 | 2023 | Elucidation of the low-expressing erythroid CR1 phenotype by bioinformatic mining of the GATA1-driven blood-group regulome. | 2 |
| 37833411 | 2023 | Complement receptor type 1 and 2 (CR1 and CR2) gene polymorphisms and plasma protein levels are associated with the Dengue disease severity. | 0 |
| 37892204 | 2023 | The Molecular Mechanisms of Complement Receptor 1-It Is Complicated. | 1 |
| 36626386 | 2023 | Population-specific positive selection on low CR1 expression in malaria-endemic regions. | 0 |
| 36924837 | 2023 | Genetic variant in complement receptor 1 (CR1, CD35) is associated with a cluster of severe fatal COVID-19 in a family. | 1 |
| 37591894 | 2023 | Elucidation of the low-expressing erythroid CR1 phenotype by bioinformatic mining of the GATA1-driven blood-group regulome. | 2 |
| 37833411 | 2023 | Complement receptor type 1 and 2 (CR1 and CR2) gene polymorphisms and plasma protein levels are associated with the Dengue disease severity. | 0 |
| 37892204 | 2023 | The Molecular Mechanisms of Complement Receptor 1-It Is Complicated. | 1 |
| 36591264 | 2022 | Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood. | 4 |
| 36755365 | 2022 | Erythrocyte complement receptor 1 (ECR1) and erythrocyte-bound C4d (EC4d) in the prediction of poor pregnancy outcomes in systemic lupus erythematosus (SLE). | 2 |
| 36591264 | 2022 | Complement C3b contributes to Escherichia coli-induced platelet aggregation in human whole blood. | 4 |
| 36755365 | 2022 | Erythrocyte complement receptor 1 (ECR1) and erythrocyte-bound C4d (EC4d) in the prediction of poor pregnancy outcomes in systemic lupus erythematosus (SLE). | 2 |
| 33334893 | 2021 | A novel soluble complement receptor 1 fragment with enhanced therapeutic potential. | 9 |
Citation
Dessen P
CR1 (complement C3b/C4b receptor 1 (Knops blood group))
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46094/cr1
