CRB3 (crumbs cell polarity complex component 3)

2019-04-01  

Identity

HGNC
CRB3
LOCATION
19p13.3
LOCUSID
92359
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 92359
MIM: 609737
HGNC: 20237
Ensembl: ENSG00000130545

Variants:

dbSNP: 92359
ClinVar: 92359
TCGA: ENSG00000130545
COSMIC: CRB3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130545ENST00000308243Q9BUF7
ENSG00000130545ENST00000356762Q9BUF7
ENSG00000130545ENST00000598494Q9BUF7
ENSG00000130545ENST00000600229Q9BUF7

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Tight junctionKEGGhsa04530
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Tight junction interactionsREACTOMER-HSA-420029

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
147185722004CRB3 binds directly to Par6 and regulates the morphogenesis of the tight junctions in mammalian epithelial cells.98
127711872003The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells.75
159764452005Multiple regions of Crumbs3 are required for tight junction formation in MCF10A cells.63
176463952007A novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta interactions.59
234396802013The WD40 protein Morg1 facilitates Par6-aPKC binding to Crb3 for apical identity in epithelial cells.13
254060122015Cell polarity protein CRB3 is an independent favorable prognostic factor for clear cell renal cell carcinoma.10
280798912017CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells.10
262170162015CRB3A Controls the Morphology and Cohesion of Cancer Cells through Ehm2/p114RhoGEF-Dependent Signaling.7
296021992018Elevated CRB3 expression suppresses breast cancer stemness by inhibiting β-catenin signalling to restore tamoxifen sensitivity.7
179881532007Overexpression of human CRB1 or related isoforms, CRB2 and CRB3, does not regulate the human presenilin complex in culture cells.3

Citation

Dessen P

CRB3 (crumbs cell polarity complex component 3)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57811/crb3