CREB3L1 (cAMP responsive element binding protein 3 like 1)

2007-12-01  

Identity

HGNC
LOCATION
11p11.2
LOCUSID
ALIAS
OASIS,OI16
FUSION GENES

Other Information

Locus ID:

NCBI: 90993
MIM: 616215
HGNC: 18856
Ensembl: ENSG00000157613

Variants:

dbSNP: 90993
ClinVar: 90993
TCGA: ENSG00000157613
COSMIC: CREB3L1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000157613ENST00000530518H0YEU7
ENSG00000157613ENST00000534787E9PK33
ENSG00000157613ENST00000621158Q96BA8

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
MelanogenesisKEGGko04916
Huntington's diseaseKEGGko05016
Prostate cancerKEGGko05215
MelanogenesisKEGGhsa04916
Huntington's diseaseKEGGhsa05016
Prostate cancerKEGGhsa05215
Vasopressin-regulated water reabsorptionKEGGko04962
Vasopressin-regulated water reabsorptionKEGGhsa04962
Cholinergic synapseKEGGhsa04725
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Cocaine addictionKEGGhsa05030
Cocaine addictionKEGGko05030
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Hepatitis BKEGGhsa05161
Insulin secretionKEGGhsa04911
Estrogen signaling pathwayKEGGhsa04915
Estrogen signaling pathwayKEGGko04915
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Thyroid hormone synthesisKEGGhsa04918
Thyroid hormone synthesisKEGGko04918
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
Aldosterone synthesis and secretionKEGGhsa04925
Insulin resistanceKEGGhsa04931
Aldosterone synthesis and secretionKEGGko04925
Longevity regulating pathwayKEGGhsa04211

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
210414432010The CrebA/Creb3-like transcription factors are major and direct regulators of secretory capacity.50
232560412012Doxorubicin blocks proliferation of cancer cells through proteolytic activation of CREB3L1.39
217678132011The membrane-bound transcription factor CREB3L1 is activated in response to virus infection to inhibit proliferation of virus-infected cells.33
217678132011The membrane-bound transcription factor CREB3L1 is activated in response to virus infection to inhibit proliferation of virus-infected cells.33
120546252002OASIS is a transcriptional activator of CREB/ATF family with a transmembrane domain.29
177211952007Translocation-positive low-grade fibromyxoid sarcoma: clinicopathologic and molecular analysis of a series expanding the morphologic spectrum and suggesting potential relationship to sclerosing epithelioid fibrosarcoma: a study from the French Sarcoma Group.28
227058512012Activation of OASIS family, ER stress transducers, is dependent on its stabilization.22
241260592013CREB3L1 is a metastasis suppressor that represses expression of genes regulating metastasis, invasion, and angiogenesis.18
235883682013EWSR1-CREB3L1 gene fusion: a novel alternative molecular aberration of low-grade fibromyxoid sarcoma.16
244416652014Recurrent EWSR1-CREB3L1 gene fusions in sclerosing epithelioid fibrosarcoma.16

Citation

Dessen P

CREB3L1 (cAMP responsive element binding protein 3 like 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49858/creb3l1