CREB3L3 (cAMP responsive element binding protein 3 like 3)

2014-06-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
CREB-H,CREBH,HYST1481
FUSION GENES

Other Information

Locus ID:

NCBI: 84699
MIM: 611998
HGNC: 18855
Ensembl: ENSG00000060566

Variants:

dbSNP: 84699
ClinVar: 84699
TCGA: ENSG00000060566
COSMIC: CREB3L3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000060566ENST00000078445Q68CJ9
ENSG00000060566ENST00000595923Q68CJ9
ENSG00000060566ENST00000602147Q68CJ9
ENSG00000060566ENST00000602257Q68CJ9

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
MelanogenesisKEGGko04916
Huntington's diseaseKEGGko05016
Prostate cancerKEGGko05215
MelanogenesisKEGGhsa04916
Huntington's diseaseKEGGhsa05016
Prostate cancerKEGGhsa05215
Vasopressin-regulated water reabsorptionKEGGko04962
Vasopressin-regulated water reabsorptionKEGGhsa04962
Cholinergic synapseKEGGhsa04725
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Cocaine addictionKEGGhsa05030
Cocaine addictionKEGGko05030
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Hepatitis BKEGGhsa05161
Insulin secretionKEGGhsa04911
Estrogen signaling pathwayKEGGhsa04915
Estrogen signaling pathwayKEGGko04915
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Thyroid hormone synthesisKEGGhsa04918
Thyroid hormone synthesisKEGGko04918
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
Chylomicron-mediated lipid transportREACTOMER-HSA-174800
Aldosterone synthesis and secretionKEGGhsa04925
Insulin resistanceKEGGhsa04931
Aldosterone synthesis and secretionKEGGko04925
Longevity regulating pathwayKEGGhsa04211

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
196798152009ER stress controls iron metabolism through induction of hepcidin.110
216937032011Cannabinoid receptor type 1 (CB1R) signaling regulates hepatic gluconeogenesis via induction of endoplasmic reticulum-bound transcription factor cAMP-responsive element-binding protein H (CREBH) in primary hepatocytes.21
178751992007Trafficking of the bZIP transmembrane transcription factor CREB-H into alternate pathways of ERAD and stress-regulated intramembrane proteolysis.18
222620562012The role of CREB-H transcription factor in triglyceride metabolism.13
254284522015HBx induces the proliferation of hepatocellular carcinoma cells via AP1 over-expressed as a result of ER stress.8
297384352018CREBH Regulates Systemic Glucose and Lipid Metabolism.8
270292152016β-TrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H.6
264277952015Novel CREB3L3 Nonsense Mutation in a Family With Dominant Hypertriglyceridemia.5
239570072013Identification and characterization of cyclic AMP response element-binding protein H response element in the human apolipoprotein A5 gene promoter.1
120396952002Expression of cAMP-responsive element binding protein and inducible cAMP early repressor in hyperfunctioning thyroid adenomas.0

Citation

Dessen P

CREB3L3 (cAMP responsive element binding protein 3 like 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/53956/creb3l3