CREB5 (cAMP responsive element binding protein 5)

2014-09-01  

Identity

HGNC
LOCATION
7p15.1
LOCUSID
ALIAS
CRE-BPA,CREB-5,CREBPA
FUSION GENES

Other Information

Locus ID:

NCBI: 9586
MIM: 618262
HGNC: 16844
Ensembl: ENSG00000146592

Variants:

dbSNP: 9586
ClinVar: 9586
TCGA: ENSG00000146592
COSMIC: CREB5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146592ENST00000357727Q02930
ENSG00000146592ENST00000396298Q02930
ENSG00000146592ENST00000396299Q02930
ENSG00000146592ENST00000396300Q02930
ENSG00000146592ENST00000409603Q02930
ENSG00000146592ENST00000424599H9KVC5
ENSG00000146592ENST00000426500C9JN33
ENSG00000146592ENST00000498316H0YFV2

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Huntington's diseaseKEGGko05016
Prostate cancerKEGGko05215
Huntington's diseaseKEGGhsa05016
Prostate cancerKEGGhsa05215
Vasopressin-regulated water reabsorptionKEGGko04962
Vasopressin-regulated water reabsorptionKEGGhsa04962
Cholinergic synapseKEGGhsa04725
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Cocaine addictionKEGGhsa05030
Cocaine addictionKEGGko05030
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Hepatitis BKEGGhsa05161
Insulin secretionKEGGhsa04911
Estrogen signaling pathwayKEGGhsa04915
Estrogen signaling pathwayKEGGko04915
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Thyroid hormone synthesisKEGGhsa04918
Thyroid hormone synthesisKEGGko04918
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
AMPK signaling pathwayKEGGhsa04152
AMPK signaling pathwayKEGGko04152
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
Aldosterone synthesis and secretionKEGGhsa04925
Insulin resistanceKEGGhsa04931
Aldosterone synthesis and secretionKEGGko04925
Longevity regulating pathwayKEGGhsa04211

References

Pubmed IDYearTitleCitations
185198262008Molecular genetics of successful smoking cessation: convergent genome-wide association study results.130
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
254228872014LOC401317, a p53-regulated long non-coding RNA, inhibits cell proliferation and induces apoptosis in the nasopharyngeal carcinoma cell line HNE2.56
200806502010Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.46
271382882016Epigenetically regulated miR-449a enhances hepatitis B virus replication by targeting cAMP-responsive element binding protein 5 and modulating hepatocytes phenotype.15
281605482017Regulation of miRNA-29c and its downstream pathways in preneoplastic progression of triple-negative breast cancer.12
303957672019LncRNA SNHG5 affects cell proliferation, metastasis and migration of colorectal cancer through regulating miR-132-3p/CREB5.12
250760322014Involvement of the CREB5 regulatory network in colorectal cancer metastasis.8
301003982018Integrated analysis of DNA methylome and transcriptome identified CREB5 as a novel risk gene contributing to recurrent pregnancy loss.4

Citation

Dessen P

CREB5 (cAMP responsive element binding protein 5)

Atlas Genet Cytogenet Oncol Haematol. 2014-09-01

Online version: http://atlasgeneticsoncology.org/gene/54898/creb5