Identity
HGNC
LOCATION
17q21.31
LOCUSID
ALIAS
CRF-R,CRF-R-1,CRF-R1,CRF1,CRFR-1,CRFR1,CRH-R-1,CRH-R1,CRHR,CRHR1L
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1394
MIM: 122561
HGNC: 2357
Ensembl: ENSG00000120088
Variants:
dbSNP: 1394
ClinVar: 1394
TCGA: ENSG00000120088
COSMIC: CRHR1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10832 | corticosteroids | Chemical | ClinicalAnnotation, VariantAnnotation | ambiguous | PK | PD | 15128701, 18539200, 19210659, 22248724, 27523435 |
| PA165290926 | fluticasone/salmeterol | Chemical | ClinicalAnnotation | associated | PK | PD | 15128701, 18539200, 19210659, 22248724 |
| PA443450 | Asthma | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PK | PD | 15128701, 18539200, 19210659, 22248724, 27523435 |
| PA447196 | Anxiety Disorders | Disease | ClinicalAnnotation | associated | PD | 17258395 | |
| PA447321 | Depressive Disorder, Major | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | 17258395, 17467808, 24422887 | |
| PA448681 | budesonide | Chemical | ClinicalAnnotation | associated | PK | PD | 15128701, 18539200, 19210659, 22248724 |
| PA449673 | fluoxetine | Chemical | ClinicalAnnotation | associated | PD | 17258395 | |
| PA449686 | fluticasone propionate | Chemical | ClinicalAnnotation | associated | PK | PD | 15128701, 18539200, 19210659, 22248724 |
| PA451749 | triamcinolone | Chemical | ClinicalAnnotation | associated | PK | PD | 15128701, 18539200, 19210659, 22248724 |
| PA452229 | antidepressants | Chemical | ClinicalAnnotation | associated | PD | 24422887 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37891393 | 2024 | Genetic Contributions to Attachment Stability Over Time: the Roles of CRHR1 Polymorphisms. | 0 |
| 37891393 | 2024 | Genetic Contributions to Attachment Stability Over Time: the Roles of CRHR1 Polymorphisms. | 0 |
| 36280595 | 2023 | Genetic Variation, Stress, and Physiological Stress Response in Adults With Food Allergy or Celiac Disease. | 0 |
| 37216433 | 2023 | CRHR1 polymorphism at rs242941, rs242940, and rs72834580: association of symptoms improvement with intranasal corticosteroids in allergic rhinitis Jordanian patients. | 0 |
| 37543650 | 2023 | Novel corticotropin-releasing hormone receptor genes (CRHR1 and CRHR2) linkage to and association with polycystic ovary syndrome. | 1 |
| 36280595 | 2023 | Genetic Variation, Stress, and Physiological Stress Response in Adults With Food Allergy or Celiac Disease. | 0 |
| 37216433 | 2023 | CRHR1 polymorphism at rs242941, rs242940, and rs72834580: association of symptoms improvement with intranasal corticosteroids in allergic rhinitis Jordanian patients. | 0 |
| 37543650 | 2023 | Novel corticotropin-releasing hormone receptor genes (CRHR1 and CRHR2) linkage to and association with polycystic ovary syndrome. | 1 |
| 35718217 | 2022 | Relations among CRFR1 and FKBP5 genotype, cortisol, and cognitive function in aging humans: A Project FRONTIER study. | 4 |
| 35718217 | 2022 | Relations among CRFR1 and FKBP5 genotype, cortisol, and cognitive function in aging humans: A Project FRONTIER study. | 4 |
| 32886236 | 2021 | Genetic variants in the glucocorticoid pathway genes and birth weight. | 1 |
| 33725938 | 2021 | Prenatal and postnatal exposure to Tangshan earthquake and CRHR1 gene polymorphism influence risk of sleep disturbance in adulthood. | 1 |
| 34279801 | 2021 | The role of rs242941, rs1876828, rs242939 and rs110402 polymorphisms of CRHR1 gene and the depression: systematic review and meta-analysis. | 1 |
| 34617831 | 2021 | Spinal pain in employees exposed to abusive supervision: Evidence of a sex and CRHR1 CTC haplotype interaction. | 0 |
| 32886236 | 2021 | Genetic variants in the glucocorticoid pathway genes and birth weight. | 1 |
Citation
Dessen P
CRHR1 (corticotropin releasing hormone receptor 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46116/crhr1
