CRIM1 (cysteine rich transmembrane BMP regulator 1)

2003-12-01  

Identity

HGNC
CRIM1
LOCATION
2p22.2
LOCUSID
51232
ALIAS
CRIM-1,S52
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51232
MIM: 606189
HGNC: 2359
Ensembl: ENSG00000150938

Variants:

dbSNP: 51232
ClinVar: 51232
TCGA: ENSG00000150938
COSMIC: CRIM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000150938ENST00000280527Q9NZV1
ENSG00000150938ENST00000413985H7C1Z0
ENSG00000150938ENST00000426856H7C2T6
ENSG00000150938ENST00000428774H7C458

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
128053762003CRIM1 regulates the rate of processing and delivery of bone morphogenetic proteins to the cell surface.28
192601392009Genome-wide association study of anthropometric traits in Korcula Island, Croatia.16
124644302002CRIM1 is involved in endothelial cell capillary formation in vitro and is expressed in blood vessels in vivo.10
255616902015CRIM1 haploinsufficiency causes defects in eye development in human and mouse.8
210367352010CRIM1 is expressed at higher levels in drug-resistant than in drug-sensitive myeloid leukemia HL60 cells.6
296079332018Reduction of Membrane Protein CRIM1 Decreases E-Cadherin and Increases Claudin-1 and MMPs, Enhancing the Migration and Invasion of Renal Carcinoma Cells.6
266539682015CRIM1, a newfound cancer-related player, regulates the adhesion and migration of lung cancer cells.5
303659432019A novel role for CRIM1 in the corneal response to UV and pterygium development.4
250880372014CRIM1, the antagonist of BMPs, is a potential risk factor of cancer.3

Citation

Dessen P

CRIM1 (cysteine rich transmembrane BMP regulator 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/40148/crim1