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CRIM1 (cysteine rich transmembrane BMP regulator 1)

Identity

Alias (NCBI)CRIM-1
S52
HGNC (Hugo) CRIM1
HGNC Previous nameS52
HGNC Previous namecysteine-rich motor neuron 1
 cysteine rich transmembrane BMP regulator 1 (chordin-like)
LocusID (NCBI) 51232
Atlas_Id 40148
Location 2p22.2  [Link to chromosome band 2p22]
Location_base_pair Starts at 36355778 and ends at 36551135 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CRIM1 (2p22.3) / ANKRD12 (18p11.22)CRIM1 (2p22.3) / EEF1B2 (2q33.3)CRIM1 (2p22.3) / FEZ2 (2p22.2)
CRIM1 (2p22.3) / IQCA1 (2q37.2)CRIM1 (2p22.3) / RAPGEF5 (7p15.3)CRIM1 (2p22.3) / RNF170 (8p11.21)
CRIM1 (2p22.3) / SYNRG (17q12)CRIM1 (2p22.3) / TACR1 (2p12)IFITM1 (11p15.5) / CRIM1 (2p22.3)
MGRN1 (16p13.3) / CRIM1 (2p22.3)PPIG (2q31.1) / CRIM1 (2p22.3)TTTY14 (Yq11.222) / CRIM1 (2p22.3)
CRIM1 2p22.3 / EEF1B2 2q33.3CRIM1 2p22.3 / TACR1 2p12PPIG 2q31.1 / CRIM1 2p22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(2;2)(p12;p22) CRIM1/TACR1
t(2;2)(p22;q31) PPIG/CRIM1
t(2;2)(p22;q33) CRIM1/EEF1B2

External links

Nomenclature
HGNC (Hugo)CRIM1   2359
Cards
Entrez_Gene (NCBI)CRIM1    cysteine rich transmembrane BMP regulator 1
AliasesCRIM-1; S52
GeneCards (Weizmann)CRIM1
Ensembl hg19 (Hinxton)ENSG00000150938 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000150938 [Gene_View]  ENSG00000150938 [Sequence]  chr2:36355778-36551135 [Contig_View]  CRIM1 [Vega]
ICGC DataPortalENSG00000150938
TCGA cBioPortalCRIM1
AceView (NCBI)CRIM1
Genatlas (Paris)CRIM1
SOURCE (Princeton)CRIM1
Genetics Home Reference (NIH)CRIM1
Genomic and cartography
GoldenPath hg38 (UCSC)CRIM1  -     chr2:36355778-36551135 +  2p22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CRIM1  -     2p22.2   [Description]    (hg19-Feb_2009)
GoldenPathCRIM1 - 2p22.2 [CytoView hg19]  CRIM1 - 2p22.2 [CytoView hg38]
ImmunoBaseENSG00000150938
genome Data Viewer NCBICRIM1 [Mapview hg19]  
OMIM606189   
Gene and transcription
Genbank (Entrez)AB209139 AF167706 AK026159 AK300817 AY358371
RefSeq transcript (Entrez)NM_016441
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CRIM1
Alternative Splicing GalleryENSG00000150938
Gene ExpressionCRIM1 [ NCBI-GEO ]   CRIM1 [ EBI - ARRAY_EXPRESS ]   CRIM1 [ SEEK ]   CRIM1 [ MEM ]
Gene Expression Viewer (FireBrowse)CRIM1 [ Firebrowse - Broad ]
GenevisibleExpression of CRIM1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51232
GTEX Portal (Tissue expression)CRIM1
Human Protein AtlasENSG00000150938-CRIM1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NZV1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NZV1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NZV1
Splice isoforms : SwissVarQ9NZV1
PhosPhoSitePlusQ9NZV1
Domaine pattern : Prosite (Expaxy)ANTISTASIN (PS51252)    IGFBP_N_2 (PS51323)    VWFC_1 (PS01208)    VWFC_2 (PS50184)   
Domains : Interpro (EBI)Antistasin-like    Growth_fac_rcpt_cys_sf    Hirudin/antistatin    IGFBP-like    VWF_dom   
Domain families : Pfam (Sanger)Antistasin (PF02822)    IGFBP (PF00219)    VWC (PF00093)   
Domain families : Pfam (NCBI)pfam02822    pfam00219    pfam00093   
Domain families : Smart (EMBL)IB (SM00121)  VWC (SM00214)  VWC_out (SM00215)  
Conserved Domain (NCBI)CRIM1
Blocks (Seattle)CRIM1
SuperfamilyQ9NZV1
Human Protein Atlas [tissue]ENSG00000150938-CRIM1 [tissue]
Peptide AtlasQ9NZV1
HPRD08392
IPIIPI00009294   IPI00893268   IPI00893193   IPI00893071   
Protein Interaction databases
DIP (DOE-UCLA)Q9NZV1
IntAct (EBI)Q9NZV1
BioGRIDCRIM1
STRING (EMBL)CRIM1
ZODIACCRIM1
Ontologies - Pathways
QuickGOQ9NZV1
Ontology : AmiGOserine-type endopeptidase inhibitor activity  insulin-like growth factor-activated receptor activity  insulin-like growth factor binding  extracellular region  plasma membrane  nervous system development  negative regulation of endopeptidase activity  integral component of membrane  PDZ domain binding  insulin-like growth factor receptor signaling pathway  
Ontology : EGO-EBIserine-type endopeptidase inhibitor activity  insulin-like growth factor-activated receptor activity  insulin-like growth factor binding  extracellular region  plasma membrane  nervous system development  negative regulation of endopeptidase activity  integral component of membrane  PDZ domain binding  insulin-like growth factor receptor signaling pathway  
NDEx NetworkCRIM1
Atlas of Cancer Signalling NetworkCRIM1
Wikipedia pathwaysCRIM1
Orthology - Evolution
OrthoDB51232
GeneTree (enSembl)ENSG00000150938
Phylogenetic Trees/Animal Genes : TreeFamCRIM1
HOGENOMQ9NZV1
Homologs : HomoloGeneCRIM1
Homology/Alignments : Family Browser (UCSC)CRIM1
Gene fusions - Rearrangements
Fusion : MitelmanCRIM1/EEF1B2 [2p22.3/2q33.3]  
Fusion : MitelmanCRIM1/TACR1 [2p22.3/2p12]  
Fusion : MitelmanPPIG/CRIM1 [2q31.1/2p22.3]  
Fusion PortalCRIM1 2p22.3 EEF1B2 2q33.3 KIRC
Fusion PortalCRIM1 2p22.3 TACR1 2p12 KIRC
Fusion PortalPPIG 2q31.1 CRIM1 2p22.3 BRCA
Fusion : QuiverCRIM1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCRIM1 [hg38]
dbVarCRIM1
ClinVarCRIM1
MonarchCRIM1
1000_GenomesCRIM1 
Exome Variant ServerCRIM1
GNOMAD BrowserENSG00000150938
Varsome BrowserCRIM1
Genomic Variants (DGV)CRIM1 [DGVbeta]
DECIPHERCRIM1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCRIM1 
Mutations
ICGC Data PortalCRIM1 
TCGA Data PortalCRIM1 
Broad Tumor PortalCRIM1
OASIS PortalCRIM1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCRIM1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCRIM1
Mutations and Diseases : HGMDCRIM1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CRIM1
DgiDB (Drug Gene Interaction Database)CRIM1
DoCM (Curated mutations)CRIM1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CRIM1 (select a term)
intoGenCRIM1
Cancer3DCRIM1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606189   
Orphanet
DisGeNETCRIM1
MedgenCRIM1
Genetic Testing Registry CRIM1
NextProtQ9NZV1 [Medical]
GENETestsCRIM1
Target ValidationCRIM1
Huge Navigator CRIM1 [HugePedia]
ClinGenCRIM1
Clinical trials, drugs, therapy
MyCancerGenomeCRIM1
Protein Interactions : CTD
Pharm GKB GenePA26877
PharosQ9NZV1
Clinical trialCRIM1
Miscellaneous
canSAR (ICR)CRIM1 (select the gene name)
HarmonizomeCRIM1
DataMed IndexCRIM1
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCRIM1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Fri Jan 1 18:11:23 CET 2021
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