CRISP2 (cysteine rich secretory protein 2)

2004-05-01  

Identity

HGNC
CRISP2
LOCATION
6p12.3
LOCUSID
7180
ALIAS
CRISP-2,CT36,GAPDL5,TPX1,TSP1

Other Information

Locus ID:

NCBI: 7180
MIM: 187430
HGNC: 12024
Ensembl: ENSG00000124490

Variants:

dbSNP: 7180
ClinVar: 7180
TCGA: ENSG00000124490
COSMIC: CRISP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124490ENST00000339139P16562
ENSG00000124490ENST00000339139A0A024RD74
ENSG00000124490ENST00000616725P16562
ENSG00000124490ENST00000616725A0A024RD74
ENSG00000124490ENST00000618917P16562

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
230279752012Pathogen-Related Yeast (PRY) proteins and members of the CAP superfamily are secreted sterol-binding proteins.35
206255112010Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis.17
255051942015The expression of cysteine-rich secretory protein 2 (CRISP2) and its specific regulator miR-27b in the spermatozoa of patients with asthenozoospermia.13
157348962005Human testicular protein TPX1/CRISP-2: localization in spermatozoa, fate after capacitation and relevance for gamete interaction.8
267861792016Fertilization defects in sperm from Cysteine-rich secretory protein 2 (Crisp2) knockout mice: implications for fertility disorders.7
275174832017MicroRNA-27a-mediated repression of cysteine-rich secretory protein 2 translation in asthenoteratozoospermic patients.7
286986032017Identification of differentially methylated BRCA1 and CRISP2 DNA regions as blood surrogate markers for cardiovascular disease.7
185505102008Polymorphisms in the human cysteine-rich secretory protein 2 (CRISP2) gene in Australian men.5
185505102008Polymorphisms in the human cysteine-rich secretory protein 2 (CRISP2) gene in Australian men.5
236615012013Human sperm CRISP2 is released from the acrosome during the acrosome reaction and re-associates at the equatorial segment.4

Citation

Dessen P

CRISP2 (cysteine rich secretory protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2004-05-01

Online version: http://atlasgeneticsoncology.org/gene/43097/crisp2