CRTC3 (CREB regulated transcription coactivator 3)

2008-05-01  

Identity

HGNC
LOCATION
15q26.1
LOCUSID
ALIAS
TORC-3,TORC3
FUSION GENES

Other Information

Locus ID:

NCBI: 64784
MIM: 608986
HGNC: 26148
Ensembl: ENSG00000140577

Variants:

dbSNP: 64784
ClinVar: 64784
TCGA: ENSG00000140577
COSMIC: CRTC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140577ENST00000268184Q6UUV7
ENSG00000140577ENST00000420329Q6UUV7
ENSG00000140577ENST00000558005H0YK64
ENSG00000140577ENST00000560098H0YK33

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Mitochondrial biogenesisREACTOMER-HSA-1592230
Transcriptional activation of mitochondrial biogenesisREACTOMER-HSA-2151201
Circadian ClockREACTOMER-HSA-400253

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
169804082006Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells.111
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
211644812010CRTC3 links catecholamine signalling to energy balance.58
215366652011Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells.23
154664682004Enhanced activation of tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3.21
180503042008A new type of MAML2 fusion in mucoepidermoid carcinoma.15
197497402009Clinicopathological significance of the CRTC3-MAML2 fusion transcript in mucoepidermoid carcinoma.15
176445182007BCL3 acts as a negative regulator of transcription from the human T-cell leukemia virus type 1 long terminal repeat through interactions with TORC3.14
284382922017Correlation of Crtc1/3-Maml2 fusion status, grade and survival in mucoepidermoid carcinoma.12
216684762011Impact of CRTC1/3-MAML2 fusions on histological classification and prognosis of mucoepidermoid carcinoma.7

Citation

Dessen P

CRTC3 (CREB regulated transcription coactivator 3)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50126/crtc3