CRY1 (cryptochrome circadian regulator 1)

2004-04-01  

Identity

HGNC
CRY1
LOCATION
12q23.3
LOCUSID
1407
ALIAS
DSPD,PHLL1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1407
MIM: 601933
HGNC: 2384
Ensembl: ENSG00000008405

Variants:

dbSNP: 1407
ClinVar: 1407
TCGA: ENSG00000008405
COSMIC: CRY1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000008405ENST00000008527Q16526
ENSG00000008405ENST00000008527A2I2P0
ENSG00000008405ENST00000549356H0YHT0

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Circadian rhythmKEGGko04710
Circadian rhythmKEGGhsa04710
Circadian ClockREACTOMER-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expressionREACTOMER-HSA-1368108

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447199Bipolar DisorderDiseaseClinicalAnnotationassociatedPD
PA450243lithiumChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
200721162010Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder.91
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
182285282008Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm.60
199343272009Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study.51
181957152008Genotype patterns that contribute to increased risk for or protection from developing heroin addiction.37
184302262008Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK.37
261682772015Acute Sleep Loss Induces Tissue-Specific Epigenetic and Transcriptional Alterations to Circadian Clock Genes in Men.36
166280072006Post-translational regulation of circadian transcriptional CLOCK(NPAS2)/BMAL1 complex by CRYPTOCHROMES.35
196938012010PER2 variantion is associated with depression vulnerability.31
218468182011Genetic variants in the LEPR, CRY1, RNASEL, IL4, and ARVCF genes are prognostic markers of prostate cancer-specific mortality.31

Citation

Dessen P

CRY1 (cryptochrome circadian regulator 1)

Atlas Genet Cytogenet Oncol Haematol. 2004-04-01

Online version: http://atlasgeneticsoncology.org/gene/40154/cry1