Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 1407
MIM: 601933
HGNC: 2384
Ensembl: ENSG00000008405
Variants:
dbSNP: 1407
ClinVar: 1407
TCGA: ENSG00000008405
COSMIC: CRY1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000008405 | ENST00000008527 | Q16526 |
| ENSG00000008405 | ENST00000008527 | A2I2P0 |
| ENSG00000008405 | ENST00000549356 | H0YHT0 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Circadian rhythm | KEGG | ko04710 |
| Circadian rhythm | KEGG | hsa04710 |
| Circadian Clock | REACTOME | R-HSA-400253 |
| BMAL1:CLOCK,NPAS2 activates circadian gene expression | REACTOME | R-HSA-1368108 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA447199 | Bipolar Disorder | Disease | ClinicalAnnotation | associated | PD | ||
| PA450243 | lithium | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38199564 | 2024 | Circadian modulation of glucose utilization via CRY1-mediated repression of Pdk1 expression. | 0 |
| 38522484 | 2024 | Cryptochrome 1 regulates ovarian granulosa cell senescence through NCOA4-mediated ferritinophagy. | 0 |
| 38199564 | 2024 | Circadian modulation of glucose utilization via CRY1-mediated repression of Pdk1 expression. | 0 |
| 38522484 | 2024 | Cryptochrome 1 regulates ovarian granulosa cell senescence through NCOA4-mediated ferritinophagy. | 0 |
| 37580741 | 2023 | The interaction between CRY1 Polymorphism and Alternative Healthy Eating Index (AHEI) on cardiovascular risk factors in overweight women and women with obesity: a cross-sectional study. | 1 |
| 37606043 | 2023 | Cry1Δ11 mutation induces ADHD-like symptoms through hyperactive dopamine D1 receptor signaling. | 1 |
| 37580741 | 2023 | The interaction between CRY1 Polymorphism and Alternative Healthy Eating Index (AHEI) on cardiovascular risk factors in overweight women and women with obesity: a cross-sectional study. | 1 |
| 37606043 | 2023 | Cry1Δ11 mutation induces ADHD-like symptoms through hyperactive dopamine D1 receptor signaling. | 1 |
| 35216153 | 2022 | Circadian Gene cry Controls Tumorigenesis through Modulation of Myc Accumulation in Glioblastoma Cells. | 2 |
| 35216153 | 2022 | Circadian Gene cry Controls Tumorigenesis through Modulation of Myc Accumulation in Glioblastoma Cells. | 2 |
| 33141439 | 2021 | Cryptochrome 1 is modulated by blue light in human keratinocytes and exerts positive impact on human hair growth. | 6 |
| 33452241 | 2021 | The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair. | 42 |
| 33650658 | 2021 | Circadian clock protein CRY1 prevents paclitaxel‑induced senescence of bladder cancer cells by promoting p53 degradation. | 18 |
| 33709300 | 2021 | Analysis of Evolution and Ethnic Diversity at Glucose-Associated SNPs of Circadian Clock-Related Loci with Cryptochrome 1, Cryptochrome 2, and Melatonin receptor 1B. | 2 |
| 33808431 | 2021 | Assessment of Selected Clock Proteins (CLOCK and CRY1) and Their Relationship with Biochemical, Anthropometric, and Lifestyle Parameters in Hypertensive Patients. | 3 |
Citation
Dessen P
CRY1 (cryptochrome circadian regulator 1)
Atlas Genet Cytogenet Oncol Haematol. 2004-04-01
Online version: http://atlasgeneticsoncology.org/gene/40154/cry1
