CRY2 (cryptochrome circadian regulator 2)

2003-12-01  

Identity

HGNC
CRY2
LOCATION
11p11.2
LOCUSID
1408
ALIAS
HCRY2,PHLL2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1408
MIM: 603732
HGNC: 2385
Ensembl: ENSG00000121671

Variants:

dbSNP: 1408
ClinVar: 1408
TCGA: ENSG00000121671
COSMIC: CRY2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121671ENST00000417225Q49AN0
ENSG00000121671ENST00000443527A0A0D2X7Z3
ENSG00000121671ENST00000616080Q49AN0
ENSG00000121671ENST00000616080A2I2P1
ENSG00000121671ENST00000616623A0A0D2X7Z3

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Circadian rhythmKEGGko04710
Circadian rhythmKEGGhsa04710
Circadian ClockREACTOMER-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expressionREACTOMER-HSA-1368108

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
200818582010New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.925
200721162010Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder.91
165287482006Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder.88
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
182285282008Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm.60
157519562005Role of structural plasticity in signal transduction by the cryptochrome blue-light photoreceptor.55
199343272009Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study.51
198399952009Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia.49
184442432008Disturbance of circadian gene expression in hepatocellular carcinoma.48

Citation

Dessen P

CRY2 (cryptochrome circadian regulator 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/40155/cry2